Effect of unilateral nasal obstruction on tongue protrusion forces in growing rats
Effect of unilateral nasal obstruction on tongue protrusion forces in growing rats
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DOI：
10.1152/japplphysiol.01152.2014
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发表时间：
2015-05-01
影响因子：
3.3
通讯作者：
Ono, Takashi
中科院分区：
文献类型：
--
作者：
Koecklin, Karin Harumi Uchima;Kato, Chiho;Ono, Takashi
鼻塞引起的口呼吸影响颅面结构的正常生长和发育，包括口面部肌肉的变化。舌肌在咽部呼吸道通畅中起着重要作用，呼吸模式的改变可能会影响舌头的功能。本研究的目的是评价生长期单侧鼻塞对舌前肌收缩特性的影响。6日龄雄性Wistar大鼠60只，随机分为对照组和实验组，每组30只。实验组大鼠于8日龄烧灼外鼻孔后造成单侧鼻塞，分别于5、7、9wk测定肌肉收缩特性。测定的具体参数有：扭体力、收缩时间、半衰期、强直力和疲劳指数。组间和组内统计比较采用重复测量多变量方差分析。各年龄段实验组肌痉挛缩力和半衰变时间均显著增加。实验组各年龄段60和80赫兹的力值均显著高于对照组。试验组疲劳指数在5wk时显著降低。这些结果提示，早期单侧鼻塞可增加舌前肌的收缩力，延长肌肉收缩的持续时间，从而影响颅面复合体的形态和发育。
Mouth breathing caused by nasal obstruction affects the normal growth and development of craniofacial structures, including changes in the orofacial muscles. Tongue muscles play an important role in patency of the pharyngeal airway, and changes in the breathing pattern may influence tongue function. The purpose of this study was to evaluate the effect of unilateral nasal obstruction during growth on contractile properties of the tongue-protruding muscles. Sixty 6-day-old male Wistar albino rats were divided randomly into control (n = 30) and experimental (n = 30) groups. Rats in the experimental group underwent a unilateral nasal obstruction after cauterization of the external nostril at the age of 8 days, and muscle contractile characteristics were measured at 5, 7, and 9 wk of age. The specific parameters measured were twitch force, contraction time, half-decay time, tetanic force, and fatigue index. Repeated-measures multivariate analysis of variance was used for intergroup and intragroup statistical comparisons. Twitch contraction force and half-decay time were significantly increased in the experimental group at all ages. Tetanic forces at 60 and 80 Hz were significantly higher in the experimental group at all ages. The fatigue index was decreased significantly in the experimental group at the age of 5 wk. These results suggest that early unilateral nasal obstruction may increase the contraction force of the tongue-protruding muscles and prolong the duration of muscle contraction, which may influence the shape and development of the craniofacial complex.