Deficits in allothetic and idiothetic spatial behavior in rats with posterior cingulate cortex lesions
Deficits in allothetic and idiothetic spatial behavior in rats with posterior cingulate cortex lesions
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DOI：
10.1016/s0166-4328(00)00312-0
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发表时间：
2001-01-08
影响因子：
2.7
通讯作者：
Kolb, B
中科院分区：
文献类型：
--
作者：
Whishaw, IQ;Maaswinkel, H;Kolb, B
扣带皮层在连接新皮层和边缘结构方面起着核心作用，这些结构涉及同种导航，一种需要使用外部线索的导航形式。动物也可以使用独特的线索来导航，这是由自我运动产生的线索。但是，对于扣带皮层是否也在个体导航中发挥作用，还没有明确的测试。采用前扣带（额内侧）和后扣带皮层（脾后）抽吸消融的大鼠被训练在开放的桌子上寻找大的食物颗粒。测量了他们带着食物回家的准确性。在这项独特的任务中，它们在红外光下从一个新的起始位置寻找食物，表面嗅觉线索被转移。大鼠还接受了两项异体导航测试。他们被测试了一个匹配地点的任务，在这个任务中，他们在正常的房间灯光下，从一系列连续出现的新地点寻找食物，他们被训练在游泳池里找到一个隐藏的平台（莫里斯地点任务）。后扣带皮层损伤组在所有的导航任务中表现出严重的缺陷，而前扣带皮层损伤组在独特任务中没有缺陷，在其他任务中只有中度缺陷。结果表明，后扣带区在个体导航中起着重要作用。(C) 2001 Elsevier Science B.V.版权所有
The cingulate cortex plays a central role in bridging neocortical and limbic structures involved in allothetic navigation, a form of navigation requiring the use of external cues. Animals can also navigate using idiothetic cues, which are cues generated by self-movement. but there have been no definitive tests of whether cingulate cortex also plays a role in idiothetic navigation. Rats with anterior cingulate (medial frontal) and posterior cingulate cortex (retrosplenial) suction ablations were trained to search for large food pellets on an open table. and the accuracy with which they returned home with the food was measured. In the idiothetic task they searched for food from a novel starting location under infrared light, and with surface olfactory cues displaced. The rats also received two tests of allothetic navigation. They were tested on a matching to-place task in which they foraged for food from a number of successively presented new locations under normal room light, and they were trained to locate a hidden platform in a swimming pool (Morris place task). The group with posterior cingulate cortex lesions was severely impaired on all of the navigation tasks whereas the group with anterior cingulate cortex lesions displayed no deficit on the idiothetic task and only moderate deficits on the other tasks. The results demonstrate a role for posterior cingulate region in idiothetic navigation. (C) 2001 Elsevier Science B.V. All rights reserved.