2-STAGE SELECTION AND TESTING DESIGNS FOR COMPARATIVE CLINICAL-TRIALS
2-STAGE SELECTION AND TESTING DESIGNS FOR COMPARATIVE CLINICAL-TRIALS
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DOI：
10.1093/biomet/75.2.303
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发表时间：
1988-06-01
期刊：
影响因子：
2.7
通讯作者：
ELLENBERG, SS
中科院分区：
文献类型：
--
作者：
THALL, PF;SIMON, R;ELLENBERG, SS
A two-stage design which selects the best of several experimental treatments and compares it to a standard control is proposed. The design allows early termination with acceptance of the global null hypothesis. Optimal sample size and cut-off parameters are obtained by minimizing expected total sample size for fixed significance level and power.
