Plasmodium yoelii:: The effect of second blood meal and anti-sporozoite antibodies on development and gene expression in the mosquito vector, Anopheles stephensi
Plasmodium yoelii:: The effect of second blood meal and anti-sporozoite antibodies on development and gene expression in the mosquito vector, Anopheles stephensi
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DOI：
10.1016/j.exppara.2006.09.007
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发表时间：
2007-03-01
影响因子：
2.1
通讯作者：
Silveira, H.
中科院分区：
文献类型：
--
作者：
Lopes, L. F.;Abrantes, P.;Silveira, H.
疟原虫的孢子生殖发育在蚊子体内进行，受多种因素调节，其中血粉的含量可直接或间接地通过蚊子对感染的反应影响疟原虫的发育。我们研究了先前感染的蚊子的第二次血餐的效果和抗子孢子免疫血清对寄生虫发育和蚊子对感染的反应的效果。分析了约氏疟原虫和斯氏按蚊的感染率、感染强度和基因表达。我们证实了第二次血餐及其免疫状态会干扰寄生虫的发育以及疟原虫和蚊子的基因表达。(c)2006年爱思唯尔公司All rights reserved.
The sporogonic development of the malaria parasite takes place in the mosquito and a wide range of factors modulates it. Among those, the contents of the blood meal can influence the parasite development directly or indirectly through the mosquito response to the infection. We have studied the effect of a second blood meal in previously infected mosquitoes and the effect of anti-sporozoite immune serum on parasite development and mosquito response to the infection. The prevalence and intensity of infection and gene expression of both Plastnodium yoelii and Anopheles stephensi was analyzed. We verified that a second blood meal and its immune status interfere with parasite development and with Plasmodium and mosquito gene expression. (c) 2006 Elsevier Inc. All rights reserved.