Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: stoichiometric process.
Asymmetric Ni(II)/Cr(II)-mediated coupling reaction: stoichiometric process.
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不对称 Ni(II)/Cr(II) 介导的偶联反应：化学计量过程。
DOI：
10.1021/ol0269805
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发表时间：
2002
期刊：
影响因子：
5.2
通讯作者：
Kishi,Yoshito
中科院分区：
文献类型：
--
作者：
Wan,Zhao-Kui;Choi,Hyeong-Wook;Kang,Fu-An;Nakajima,Katsumasa;Demeke,Damtew;Kishi,Yoshito
X-射线分析表明，含有R1=I-Pr、R2=Me和R3=Me的磺酰胺是铬(III)盐的三齿配体。这类配体以R1=t-Bu，R2=2-萘基和R3=Me为代表，能有效地实现不对称的Ni/Cr偶联反应，并且，以喜树碱的C14-C38片段为例，它的合成潜力已被证明。提出了该过程的一种可能机理。
Via an X-ray analysis, the sulfonamide bearing R1=i-Pr, R2= Me, and R3= Me is shown to be a tridentate ligand to a Cr(III) salt. This class of ligands, represented by R1=t-Bu, R2= 2-naphthyl, and R3= Me, is effective to achieve an asymmetric Ni/Cr-mediated coupling reaction and, with the C14-C38 segment of halichondrins, its synthetic potential has been demonstrated. A possible mechanism is suggested for the process.