Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy.
Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy.
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DOI：
10.1101/cshperspect.a022384
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发表时间：
2016-03-01
影响因子：
5.4
通讯作者：
Poolos NP
中科院分区：
文献类型：
--
作者：
Brennan GP;Baram TZ;Poolos NP
癫痫是一种常见的脑部疾病，其特征是自发性癫痫发作。这些同步放电的爆发是由神经元网络的异常引起的。单个神经元和神经元网络的兴奋性很大程度上受离子通道控制，实际上，由于突变或异常表达和运输而导致的许多离子通道的异常，是几种类型癫痫的基础。在这里，我们重点关注传导 Ih 电流的超极化激活的环核苷酸调节离子通道 (HCN)。这种电导在神经元和网络兴奋性的调节中发挥着复杂而多样的作用。我们描述了 HCN 通道的正常功能，并讨论了异常表达、组装、运输和翻译后修饰如何导致实验和人类癫痫。
Epilepsy is a common brain disorder characterized by the occurrence of spontaneous seizures. These bursts of synchronous firing arise from abnormalities of neuronal networks. Excitability of individual neurons and neuronal networks is largely governed by ion channels and indeed abnormalities of a number of ion channels resulting from mutations or aberrant expression and trafficking, underlies several types of epilepsy. Here we focus on the hyperpolarization-activated cyclic nucleotide regulated ion channels (HCN) that conduct Ih current. This conductance plays complex and diverse roles in the regulation of neuronal and network excitability. We describe the normal function of HCN channels and discuss how aberrant expression, assembly, trafficking and post-translational modifications contribute to experimental and human epilepsy.