Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.
Upregulation of HYAL1 expression in breast cancer promoted tumor cell proliferation, migration, invasion and angiogenesis.
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DOI：
10.1371/journal.pone.0022836
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Ren GS
中科院分区：
文献类型：
--
作者：
Tan JX;Wang XY;Su XL;Li HY;Shi Y;Wang L;Ren GS
Hyaluronic acid (HA) is a component of the Extra-cellular matrix (ECM), it is closely correlated with tumor cell growth, proliferation, metastasis and angiogenesis, etc. Hyaluronidase (HAase) is a HA-degrading endoglycosidase, levels of HAase are elevated in many cancers. Hyaluronidase-1 (HYAL1) is the major tumor-derived HAase. We previously demonstrated that HYAL1 were overexpression in human breast cancer. Breast cancer cells with higher HAase expression, exhibited significantly higher invasion ability through matrigel than those cells with lower HAase expression, and knockdown of HYAL1 expression in breast cancer cells resulted in decreased cell growth, adhesion, invasion and angiogenesis. Here, to further elucidate the function of HYAL1 in breast cancer, we investigated the consequences of forcing HYAL1 expression in breast cancer cells by transfection of expression plasmid. Compared with control, HYAL1 up-regulated cells showed increased the HAase activity, and reduced the expression of HA in vitro. Meantime, upregulation of HYAL1 promoted the cell growth, migration, invasion and angiogenesis in vitro. Moreover, in nude mice model, forcing HYAL1 expression induced breast cancer cell xenograft tumor growth and angiogenesis. Interestingly, the HA expression was upregulated by forcing HYAL1 expression in vivo. These findings suggested that HYAL1-HA system is correlated with the malignant behavior of breast cancer.
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影响因子：
6
作者：
Simpson, MA;Wilson, CM;McCarthy, JB
通讯作者：
McCarthy, JB
影响因子：
9.7
作者：
Lin, G;Stern, R
通讯作者：
Stern, R
影响因子：
3.8
作者：
Nykopp TK;Rilla K;Tammi MI;Tammi RH;Sironen R;Hämäläinen K;Kosma VM;Heinonen S;Anttila M
通讯作者：
Anttila M
DOI：
10.1073/pnas.93.15.7832
发表时间：
1996-07-23
影响因子：
11.1
作者：
Liu, DC;Pearlman, E;Sy, MS
通讯作者：
Sy, MS
影响因子：
11.2
作者：
Lokeshwar, VB;Cerwinka, WH;Lokeshwar, BL
通讯作者：
Lokeshwar, BL