Malignant Melanoma Developing in an Area of Palmoplantar Keratoderma (Greither's Disease)
Malignant Melanoma Developing in an Area of Palmoplantar Keratoderma (Greither's Disease)
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掌跖角化病（格雷瑟氏病）区域发生恶性黑色素瘤
DOI：
10.1111/j.1346-8138.1995.tb03342.x
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
S. Arase
中科院分区：
文献类型：
--
作者：
T. Seike;H. Nakanishi;Y. Urano;S. Arase
我们报告一例恶性黑色素瘤发生在过度角化的唯一的患者掌跖角化病（PPK）。在双手和双脚的背侧以及肘部和膝盖的伸肌方面也观察到角化过度病变。患者的PPK似乎是由常染色体显性基因传播的。组织学上，过度角化病变表现为棘皮症、明显的过度角化（无角化不全）和过度颗粒化。
We report a case of malignant melanoma arising on the hyperkeratotic sole of a patient with palmoplantar keratoderma (PPK). Hyperkeratotic lesions were also seen on the dorsa of both hands and feet and the extensor aspects of elbows and knees. The patient's PPK appeared to have been transmitted by an autosomal dominant gene. Histologically, the hyperkeratotic lesions showed acanthosis, marked hyperkeratosis without parakeratosis, and hypergranulosis.