Effect of Moxibustion on HIF-1α and VEGF Levels in Patients with Rheumatoid Arthritis
Effect of Moxibustion on HIF-1α and VEGF Levels in Patients with Rheumatoid Arthritis
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DOI：
10.1155/2019/4705247
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发表时间：
2019-11-27
影响因子：
2.9
通讯作者：
Wu, Ping
中科院分区：
文献类型：
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作者：
Gong, Yuanyuan;Yu, Zeyun;Wu, Ping
背景艾灸对类风湿关节炎（RA）有消肿止痛作用，但其作用机制尚不清楚。Objective.观察艾灸对类风湿关节炎（RA）患者血清缺氧诱导因子-1 α（HIF-1 alpha）和血管内皮生长因子（VEGF）水平的影响，探讨艾灸治疗RA的可能机制。方法.本研究纳入了46例符合纳入标准的RA患者，并以相等的比例随机分配到治疗组和对照组。对照组给予甲氨蝶呤或来氟米特治疗，治疗组给予甲氨蝶呤或来氟米特治疗并艾灸足三里、肾俞、阿是穴。比较两组患者干预前后的临床症状、RA相关血清标志物以及血清TNF-α、IL-1 β、HIF-1 α和VEGF水平。采用SPSS21.0统计软件进行统计学分析。结果46例RA患者中37例最终完成整个疗程。与对照组比较，治疗组临床症状改善明显（P0. 05）。治疗8周后各组TNF-α、IL-1 β水平差异有统计学意义（P
Background. Moxibustion has a therapeutic effect of reducing swelling and relieving pain in patients with rheumatoid arthritis (RA) but its mechanism is uncertain. Objective. To evaluate the effect of moxibustion on serum levels of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) in patients with RA and to explore the possible mechanism of moxibustion. Methods. This study involved 46 RA patients who had fulfilled the inclusion criteria and were randomly assigned to a treatment group and a control group in an equal ratio. The control group was treated with methotrexate or leflunomide, while the treatment group received methotrexate or leflunomide and moxibustion at ST 36 (Zusanli), BL 23 (Shenshu), and Ashi points. Patients' clinical symptoms, RA-associated serum markers, and serum levels of TNF-alpha, IL-1 beta, HIF-1 alpha, and VEGF were compared in the two groups before and after intervention. Statistical analysis was performed using SPSS 21.0 statistical software. Results. 37 of 46 RA patients eventually completed the whole treatment course. Compared with the control group, the treatment group significantly improved the clinical symptoms (P0.05). There were significant differences in TNF-alpha and IL-1 beta among the groups after 8 weeks of treatment (P