Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress - The framingham heart study
Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress - The framingham heart study
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DOI：
10.1161/circulationaha.107.710509
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发表时间：
2007-09-11
期刊：
影响因子：
37.8
通讯作者：
Fox, Caroline S.
中科院分区：
文献类型：
--
作者：
Pou, Karla M.;Massaro, Joseph M.;Fox, Caroline S.
背景——过度肥胖与更大的全身炎症有关。内脏脂肪是否比腹部皮下脂肪更具促炎性尚不清楚。方法和结果——我们检查了 1250 名弗雷明汉心脏研究参与者（52% 为女性；年龄 60+/-9 岁）的腹部皮下脂肪组织 (SAT) 和内脏脂肪组织 (VAT) 与循环炎症和氧化应激生物标志物的关系，并通过多探测器计算机断层扫描进行评估。在调整年龄、性别、吸烟、体力活动、更年期、激素替代疗法、酒精和阿司匹林使用后，检查生物标志物与 SAT 和 VAT 增量的关系；其他模型包括体重指数和腰围。 SAT 和 VAT 与 C 反应蛋白、纤维蛋白原、细胞间粘附分子 1、白细胞介素 6、P-选择素和肿瘤坏死因子受体 2 呈正相关（就关联强度而言）（多变量模型 R-2 0.06 至 0.28 [ SAT] 和 0.07 至 0.29 [ VAT]）。然而，与 SAT 相比，VAT 与尿异前列烷和单核细胞趋化蛋白 1 的相关性更高（SAT 与 VAT 比较：异前列烷，R2 0.07 与 0.10，P = 0.002；单核细胞趋化蛋白-1，R2 0.07 与 0.08，P = 0.04）。当将体重指数和腰围添加到模型中时，增值税仍然仅与 C 反应蛋白（女性 P = 0.0003；男性 P = 0.006）、白细胞介素 6（P = 0.01）、异前列烷（P = 0.0002）和单核细胞趋化蛋白 1（P = 0.008）显着相关； SAT 仅与纤维蛋白原相关（P = 0.01）。结论——目前的横断面数据支持 SAT 和 VAT 与炎症和氧化应激之间的关联。数据表明，临床肥胖指标（体重指数和腰围）可能无法完全解释内脏脂肪对炎症的影响。
Background-Excess adiposity is associated with greater systemic inflammation. Whether visceral adiposity is more proinflammatory than subcutaneous abdominal adiposity is unclear. Methods and Results-We examined the relations of abdominal subcutaneous adipose tissue ( SAT) and visceral adipose tissue ( VAT), assessed by multidetector computerized tomography, to circulating inflammatory and oxidative stress biomarkers in 1250 Framingham Heart Study participants (52% women; age 60 +/- 9 years). Biomarkers were examined in relation to increments of SAT and VAT after adjustment for age, sex, smoking, physical activity, menopause, hormone replacement therapy, alcohol, and aspirin use; additional models included body mass index and waist circumference. SAT and VAT were positively and similarly ( with respect to strength of association) related to C-reactive protein, fibrinogen, intercellular adhesion molecule-1, interleukin-6, P-selectin, and tumor necrosis factor receptor-2 (multivariable model R-2 0.06 to 0.28 [ SAT] and 0.07 to 0.29 [ VAT]). However, compared with SAT, VAT was more highly associated with urinary isoprostanes and monocyte chemoattractant protein-1 ( SAT versus VAT comparison: isoprostanes, R2 0.07 versus 0.10, P = 0.002; monocyte chemoattractant protein-1, R2 0.07 versus 0.08, P = 0.04). When body mass index and waist circumference were added to the models, VAT remained significantly associated with only C-reactive protein ( P = 0.0003 for women; P = 0.006 for men), interleukin-6 ( P = 0.01), isoprostanes ( P = 0.0002), and monocyte chemoattractant protein-1 ( P = 0.008); SAT only remained associated with fibrinogen ( P = 0.01). Conclusions-The present cross-sectional data support an association between both SAT and VAT with inflammation and oxidative stress. The data suggest that the contribution of visceral fat to inflammation may not be completely accounted for by clinical measures of obesity ( body mass index and waist circumference).