Intraocular penetration of vancomycin eye drops after application to the medial canthus with closed lids
Intraocular penetration of vancomycin eye drops after application to the medial canthus with closed lids
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DOI：
10.1136/bjo.84.3.300
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发表时间：
2000-03-01
影响因子：
4.1
通讯作者：
Loewenstein, A
中科院分区：
文献类型：
--
作者：
Alster, Y;Herlin, L;Loewenstein, A
目的-为了探讨万古霉素滴眼液的眼内渗透，并比较滴入到较低的盲囊的常规方法与应用滴到内眦与close lids. Methods-这项前瞻性随机试验评价了53例患者的53只眼谁经历了囊外白内障摘除术（ECCE）与眼内透镜植入。万古霉素将（50 mg/ml）滴眼液涂在打开眼睑的下盲管上（常规方法），或在患者处于仰卧位且眼睑闭合的情况下向内眦进行;在幼儿保育和教育期间进行穿刺后，取房水样品，用TDX万古霉素测定法测定万古霉素浓度结果：在两种滴注方法中，前房中万古霉素浓度均高于革兰氏阳性菌的最低抑菌浓度（2.04（SD 1.9）μ g/ml和1.49（1.1）μ g/ml，分别在开放和闭合方法中（p=0.202））。当将滴剂应用于下盲囊或闭合眼睑的内眦时，达到了相当的浓度。后一种方法被认为有可能提高患者的依从性。
Aims-To investigate the intraocular penetration of vancomycin eye drops and to compare the conventional method of drop instillation to the lower cul de sac with applying drops to the medial canthus with closed lids.Methods-This prospective randomised trial evaluated 53 eyes of 53 patients who had undergone extracapsular cataract extraction (ECCE) with intraocular lens implantation. Vancomycin (50 mg/ml) eye drops were applied to either the lower cul de sac with open lids (conventional method), or to the medial canthus with the patient in a supine position and with closed lids; After paracentesis performed during ECCE, an aqueous humour sample was taken and vancomycin concentration was measured using the TDX vancomycin assay (fluorescence polarisation immunoassay).Results-Vancomycin concentration in the anterior chamber were above the minimal inhibitory concentration for Gram positive bacteria in the two methods of drop instillation examined (2.04 (SD 1.9) mu g/ml and 1.49 (1.1) mu g/ml in the open and closed methods, respectively (p=0.202)).Conclusions;Vancomycin (50 mg/ml) reaches therapeutic concentration in the anterior chamber after topical drop application. Comparable concentrations were reached when drops were applied in either the lower cul de sac or to the medial canthus with closed lids. The latter method is proposed as likely to improve patient compliance.