Bone remodeling in maxilla, mandible, and femur of young dogs
Bone remodeling in maxilla, mandible, and femur of young dogs
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DOI：
10.1002/ar.20619
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发表时间：
2008-01-01
影响因子：
2
通讯作者：
Beck, Frank M.
中科院分区：
文献类型：
--
作者：
Huja, Sarandeep S.;Beck, Frank M.
颌骨重塑对于代谢需求、机械需求和骨骼生长至关重要。目前，还没有关于幼犬下颌重塑的信息。四只类似 5 个月大的雄性狗被给予一对钙黄绿素骨标签。处死后，从上颌骨、下颌骨和股骨获取骨切片。颌骨标本取自与恒牙萌出相关的区域。制备未脱钙的标本，通过组织形态计量学方法进行检查，以评估支撑萌出牙和股骨的矿物质沉积率（μm/d）、矿化表面/骨表面（％）和骨形成率（BFR，％/年）。仅测量皮质内二次骨重塑单位。三个检查部位的 BFR 存在显着差异（P < 0.05），其中股骨的 BFR 最高（72%/年）。下颌骨的 BFR 是上颌骨的两倍（51%/年 vs. 25.5%/年）。幼犬的下颌和股骨的周转率与成年犬（类似于 1 岁）的下颌和四肢骨骼之间的类似比较不同。尽管股骨中的 BFR 随着年龄的增长而降低，但颌骨中的 BFR 仍然升高。
Bone remodeling in the jaw is essential for metabolic needs, mechanical demands and for growth of the skeleton. Currently, there is no information on remodeling in the jaw of young dogs. Four similar to 5-month-old male dogs were given a pair of calcein bone labels. After killing, bone sections were obtained from the maxilla, mandible, and femur. The jaw specimens were obtained from regions associated with erupting permanent teeth. Undecalcified specimens were prepared for examination by histomorphometric methods to evaluate mineral apposition rate (mu m/d), mineralizing surface/bone surface (%), and bone formation rate (BFR, %/yr) in the bone supporting erupting teeth and in the femurs. Only intracortical secondary osteonal remodeling units were measured. There were significant (P < 0.05) differences in the BFR for the three sites examined, with the highest BFR (72%/yr) being in the femur. The mandible had a BFR twofold greater than the maxilla (51%/yr vs. 25.5%/yr). The rate of turnover in the jaw and femur of young dogs is distinct from a similar comparison between the jaw and appendicular skeleton of adult (similar to 1 yr old) dogs. Although BFR decreases with age in the femur, it remains elevated in the jaws.