Long-term humoral immunity against viruses: Revisiting the issue of plasma cell longevity
Long-term humoral immunity against viruses: Revisiting the issue of plasma cell longevity
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DOI：
10.1016/0966-842x(96)10059-7
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发表时间：
1996-10-01
影响因子：
15.9
通讯作者：
Ahmed, R
中科院分区：
文献类型：
--
作者：
Slifka, MK;Ahmed, R
尽管有大量文献记载在接种疫苗或急性病毒感染后抗体反应延长，但长期抗体产生背后的机制尚不完全清楚。我们提出假设，长寿的浆细胞是长期体液免疫的重要组成部分，但在很大程度上被忽视。
Despite extensive documentation of prolonged antibody responses following vaccination or acute viral infection, the mechanisms behind long-term antibody production are nor fully understood. We propose the hypothesis that long-lived plasma cells are an important, yet largely overlooked, component of long-term humoral immunity.