An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
An estimate of the worldwide prevalence and disability associated with osteoporotic fractures
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DOI：
10.1007/s00198-006-0172-4
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发表时间：
2006-12-01
影响因子：
4
通讯作者：
Kanis, J. A.
中科院分区：
文献类型：
--
作者：
Johnell, O.;Kanis, J. A.
目的本研究的目的是量化全球骨质疏松性骨折的负担。方法采用系统评价的方法确定髋部骨折的发生率，并根据世界不同地区髋部骨折的发生率推算骨质疏松性骨折的发生率。超额死亡率和残疾权重使用来自瑞典的年龄和性别特异性数据来计算骨质疏松性骨折导致的残疾调整生命年（DALYs）损失。结果2000年估计有900万例骨质疏松性骨折，其中160万例发生在髋部，170万例发生在前臂，140万例为临床椎体骨折。骨质疏松性骨折发生率最高的是欧洲（34.8%）。损失的伤残调整生命年总数为580万，其中51%是发生在欧洲和美洲的骨折造成的。在世界范围内，骨质疏松性骨折占全球非传染性疾病负担的0.83%，在欧洲占全球负担的1.75%。在欧洲，除肺癌外，骨质疏松性骨折导致的伤残调整生命年（DALYs）损失超过了常见癌症。对于慢性肌肉骨骼疾病，欧洲因骨质疏松症（200万）导致的DALYs损失低于骨关节病（310万），但高于类风湿关节炎（100万）。结论骨质疏松性骨折是发病率和死亡率的重要原因，特别是在发达国家。
Objective The aim of this study was to quantify the global burden of osteoporotic fracture worldwide.Methods The incidence of hip fractures was identified by systematic review and the incidence of osteoporotic fractures was imputed from the incidence of hip fractures in different regions of the world. Excess mortality and disability weights used age- and sex-specific data from Sweden to calculate the Disability Adjusted Life Years (DALYs) lost due to osteoporotic fracture.Results In the year 2000 there were an estimated 9.0 million osteoporotic fractures of which 1.6 million were at the hip, 1.7 million at the forearm and 1.4 million were clinical vertebral fractures. The greatest number of osteoporotic fractures occurred in Europe (34.8%). The total DALYs lost was 5.8 million of which 51% were accounted for by fractures that occurred in Europe and the Americas. World-wide, osteoporotic fractures accounted for 0.83% of the global burden of non-communicable disease and was 1.75% of the global burden in Europe. In Europe, osteoporotic fractures accounted for more DALYs lost than common cancers with the exception of lung cancer. For chronic musculo-skeletal disorders the DALYs lost in Europe due to osteoporosis (2.0 million) were less than for osteoarthrosis (3.1 million) but greater than for rheumatoid arthritis (1.0 million).Conclusion We conclude that osteoporotic fractures are a significant cause of morbidity and mortality, particularly in the developed countries.