Metabolism of Amino Acids in Cancer.
Metabolism of Amino Acids in Cancer.
复制标题
癌症中氨基酸的代谢
DOI：
10.3389/fcell.2020.603837
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发表时间：
2020
影响因子：
5.5
通讯作者：
Yi P
中科院分区：
文献类型：
--
作者：
Wei Z;Liu X;Cheng C;Yu W;Yi P
代谢重编程已被广泛认为是恶性肿瘤的标志。在许多对特定氨基酸表现出成瘾性的癌症中，氨基酸的摄取和代谢异常上调。氨基酸促进癌细胞在基因毒性、氧化和营养应激下的存活和增殖。因此，针对氨基酸代谢正在成为癌症患者的潜在治疗策略。在这篇综述中，我们将系统总结恶性肿瘤中氨基酸代谢的最新进展，并讨论它们与哺乳动物雷帕霉素靶点复合物1 (mTORC1)信号、表观遗传修饰、肿瘤生长和免疫以及铁死亡的相互关系。最后，我们将强调潜在的治疗应用。
Metabolic reprogramming has been widely recognized as a hallmark of malignancy. The uptake and metabolism of amino acids are aberrantly upregulated in many cancers that display addiction to particular amino acids. Amino acids facilitate the survival and proliferation of cancer cells under genotoxic, oxidative, and nutritional stress. Thus, targeting amino acid metabolism is becoming a potential therapeutic strategy for cancer patients. In this review, we will systematically summarize the recent progress of amino acid metabolism in malignancy and discuss their interconnection with mammalian target of rapamycin complex 1 (mTORC1) signaling, epigenetic modification, tumor growth and immunity, and ferroptosis. Finally, we will highlight the potential therapeutic applications.