Progression level of extracapsular spread and tumor budding for cervical lymph node metastasis of OSCC
Progression level of extracapsular spread and tumor budding for cervical lymph node metastasis of OSCC
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DOI：
10.1007/s00784-017-2231-y
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发表时间：
2018-04-01
影响因子：
3.4
通讯作者：
Kurita, Hiroshi
中科院分区：
文献类型：
--
作者：
Yamada, Shin-ichi;Otsuru, Mitsunobu;Kurita, Hiroshi
将口腔鳞状细胞癌（OSCC）颈淋巴结转移的囊外扩散（ECS）进展程度分为3种类型，并重新分析其与患者预后的关系，采用Kaplan-Meier法分析总生存期（OS）和无复发生存期（RFS）曲线。对216例口腔鳞癌患者进行ECS检测，并进行单因素和多因素分析。C型患者的5年总生存率和RFS率显著较差，分别为40.6%和37.8%，C型患者在显微镜下定义为肿瘤浸润到结周脂肪或肌肉组织。单因素分析结果提示，口腔鳞状细胞癌患者的预后与其进展程度有关，尤其是C型。伴肿瘤出芽的C型患者5年RFS率明显较差，为31.5%。C型伴肿瘤出芽与局部和区域复发以及远处转移有关。多因素分析显示，肿瘤出芽是影响口腔鳞癌患者预后的独立因素，提示ECS的进展程度和肿瘤出芽是影响口腔鳞癌患者预后的重要因素，提示ECS的进展程度和肿瘤出芽是影响口腔鳞癌患者颈淋巴结转移的重要因素。
The progression level of extracapsular spread (ECS) for cervical lymph node metastasis of oral squamous cell carcinoma (OSCC) was previously divided into three types, and their relationships with the prognosis of patients were re-examined.The Kaplan-Meier method was used to examine overall survival (OS) and relapse-free survival (RFS) curves. Prognosis factor for recurrence was analyzed with univariate and multivariate analysis.ECS was detected in 216 cases of OSCC and analyzed. The 5-year overall survival and RFS rates of patients with type C, which was microscopically defined as tumor invasion to perinodal fat or muscle tissue, were significantly poor at 40.6 and 37.8%, respectively. The results of a univariate analysis suggested that the prognosis of ECS in OSCC patients is associated with its progression level, particularly type C. The 5-year RFS rate of type C with tumor budding was significantly poor at 31.5%. Type C with tumor budding correlated with local and regional recurrence as well as distant metastasis. In a multivariate analysis, tumor budding was identified as an independent prognostic factor.These results suggest that the progression level of ECS and tumor budding are useful prognostic factors in OSCC patients.This study indicated that the progression level and tumor budding of ECS for cervical lymph node metastasis were useful prognostic factors in OSCC patients.