Postmenopausal breast cancer risk and cumulative number of menstrual cycles
Postmenopausal breast cancer risk and cumulative number of menstrual cycles
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DOI：
10.1158/1055-9965.epi-04-0465
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发表时间：
2005-04-01
影响因子：
3.8
通讯作者：
Peeters, PHM
中科院分区：
文献类型：
--
作者：
Chavez-MacGregor, M;Elias, SG;Peeters, PHM
目的：探讨是否一生累积的月经周期数，作为内源性雌激素的总暴露指数，月经周期的数量，直到第一次足月妊娠（FFTP），与乳腺癌的风险在绝经后women.Methods：以人口为基础的研究，数据来自欧洲前瞻性调查癌症和营养研究。自然绝经的受试者符合条件（n = 6，718）。计算了6，031名（90%）女性的月经周期累积次数。我们计算了经产受试者中直至FFTP的周期数。在报告总是不规则的女性中，月经周期的数量是不可能计算的，因此，我们在分析中添加了“总是不规则”的类别。在46，746人年的随访期间，确定了168例乳腺癌病例。考克斯回归模型进行了调整，以考虑潜在的confers.Results：即使当我们的数据没有显示出一个明确的线性梯度，我们观察到乳腺癌的风险增加的妇女在其一生中累积月经周期的数量较高。使用：5415个周期作为参考，不规则组、416-453、454-490和2：491个周期的风险比分别为1.11（0.56，2.19）、1.88（1.14，3.12）、1.74（1.05，2.87）和1.80（1.09，2.96）。虽然没有统计学意义上的显着性，和较小的幅度，在FFTP前的周期数的风险估计显示出相同的trendity.Conclusion：在妇女谁经历了自然绝经，月经周期的一生中，更高的数量，反映了更长的内源性雌激素的暴露，与乳腺癌的风险增加。
Objective: To explore whether the lifetime cumulative number of menstrual cycles, as an index for total exposure to endogenous estrogens, and the number of menstrual cycles until a first full-term pregnancy (FFTP), are associated with breast cancer risk in postmenopausal women.Methods: Population-based study with data from the Prospect-European Prospective Investigation into Cancer and Nutrition study. Naturally menopausal participants were eligible (n = 6,718). The cumulative number of menstrual cycles was computed in 6,031 (90%) women. We calculated the number of cycles until FFTP among parous participants. The number of menstrual cycles was impossible to compute in women who reported to be always irregular, therefore, we added the "always irregular" category in the analysis. During the 46,746 person-years of follow-up, 168 breast cancer cases were identified. Cox regression models were used and adjustments were made to account for potential confounders.Results: Even when our data does not show a clear linear gradient, we observed an increased breast cancer risk in women with a higher number of cumulative menstrual cycles in their lifetime. Using :5415 cycles as reference, the hazard ratio for the irregular group, 416-453, 454-490, and 2:491 cycles was 1.11 (.56, 2.19), 1.88 (1.14, 3.12), 1.74 (1.05, 2.87), and 1.80 (1.09, 2.96), respectively. Although not statistically significant, and of less magnitude, the risk estimates for the number of cycles before FFTP showed the same tendency.Conclusion: Among women who underwent natural menopause, a higher number of menstrual cycles in lifetime, reflecting a longer exposure to endogenous estrogens, is associated with an increased breast cancer risk.