A Novel Strategy for Single-Session Ultrasound-Guided Radiofrequency Ablation of Large Benign Thyroid Nodules: A Pilot Cohort Study.
A Novel Strategy for Single-Session Ultrasound-Guided Radiofrequency Ablation of Large Benign Thyroid Nodules: A Pilot Cohort Study.
复制标题
DOI：
10.3389/fendo.2020.560508
复制
发表时间：
2020
影响因子：
5.2
通讯作者：
Ren J
中科院分区：
文献类型：
--
作者：
Yao Z;Wu T;Zheng B;Tan L;Lian Y;Liu B;Ren J
Background: Ultrasound-guided radiofrequency ablation (RFA) of thyroid nodules (TNs) is a minimally invasive procedure that has been widely used to induce volume reduction in symptomatic solid benign TNs. The goal of this study was to investigate a novel therapeutic approach for single-session ablation of large thyroid nodules (LTNs, vol > 20 ml). Methods: We performed a pilot cohort study of 21 patients with symptomatic solid benign LTNs (vol > 20 ml), who accepted ultrasound-guided RFA treatment between September 2018 and November 2019. RFA was performed using an 18-gauge internally cooled electrode with ultrasonographic guidance in a single session combined with intraoperative hydrodissection and immediate contrast-enhanced ultrasound (CEUS) to optimize safety and efficacy. Nodule volume was evaluated before ablation and at 1, 3, and 6 months after initial ablation, and all patients were asked to assess the cosmetic score (from 1 to 4) and symptom score (from 0 to 10) before ablation and at every follow-up after ablation. Results: At the 6 month follow-up, there was significant nodule volume reduction, from 27.49 ml ± 7.9 (standard deviation) to 3.82 ml ± 5.02 (p = 0.001). Cosmetic signs (p = 0.001) and pressure symptoms (p = 0.001) were significantly improved. All patients underwent RFA without any major complications, and very few patients developed a change in voice (2/21). However, the changes subsided within 1 month. Almost half of the patients received an additional RFA (11/21) treatment to achieve complete ablation on the intraoperative immediate CEUS evaluation. Conclusion: RFA is effective for treating LTNs (vol > 20 ml) and controlling clinical symptoms with a low complication rate. Patients were satisfied with cosmetic sign and pressure symptom improvement. The intraoperative hydrodissection and immediate CEUS represent a novel therapeutic approach for single-session ablation of LTNs.
登录
查看更多内容
影响因子：
4.8
作者：
Na DG;Lee JH;Jung SL;Kim JH;Sung JY;Shin JH;Kim EK;Lee JH;Kim DW;Park JS;Kim KS;Baek SM;Lee Y;Chong S;Sim JS;Huh JY;Bae JI;Kim KT;Han SY;Bae MY;Kim YS;Baek JH;Korean Society of Thyroid Radiology (KSThR);Korean Society of Radiology
通讯作者：
Korean Society of Radiology
DOI：
10.1111/j.1742-1241.2008.01875.x
发表时间：
2009-04-01
影响因子：
2.6
作者：
Jeannon, J. -P.;Orabi, A. A.;Simo, R.
通讯作者：
Simo, R.
影响因子：
6.6
作者：
Cesareo, Roberto;Pacella, Claudio Maurizio;Palermo, Andrea
通讯作者：
Palermo, Andrea
影响因子：
4.2
作者：
Gharib, Hossein;Papini, Enrico;Vitti, Paolo
通讯作者：
Vitti, Paolo
影响因子：
2.6
作者：
Baek, Jung Hwan;Moon, Won-Jin;Lee, Ducky
通讯作者：
Lee, Ducky