Correlation between indocyanine green angiographic findings and histopathology of polypoidal choroidal vasculopathy
Correlation between indocyanine green angiographic findings and histopathology of polypoidal choroidal vasculopathy
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DOI：
10.1007/s10384-003-0057-4
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发表时间：
2004-05-01
影响因子：
2.4
通讯作者：
Mori, R
中科院分区：
文献类型：
--
作者：
Nakajima, M;Yuzawa, M;Mori, R
目的：为了分析息肉状脉络膜血管病变（PCV）和由 PCV 发展而来的脉络膜新生血管（CNV）的组织病理学，作者评估了病理结果与术前吲哚菁绿血管造影（IA）结果之间的相关性。方法：在与 PCV 相关的 CNV 切除过程中获得两份标本。 PCV 组织与 CNV 一起切除。通过光学显微镜检查标本。结果：在一个病例中，IA 显示息肉状病变在早期和晚期均表现出强荧光，并且在受影响区域，在相对健康的视网膜色素上皮 (RPE) 下方通过组织学方法鉴定出异常扩张的血管。另一例，IA上可见息肉状病变，早期呈强荧光，晚期呈等荧光，RPE下可见血管扩张；存在血管周围无定形物质。两例患者的RPE均粘附在脉络膜一侧，且感觉神经视网膜下均存在CNV。 CNV 具有大量血管腔，未被 RPE 包围，并且几乎没有纤维成分。结论：IA 结果因位于 PCV 上方的 RPE 的状况以及 PCV 周围无定形材料的程度而异。 (C) 日本眼科学会 2004 年。
Purpose: To analyze the histopathology of polypoidal choroidal vasculopathy (PCV) and choroidal neovascularization (CNV) developing from PCV, the authors evaluated correlations between pathological findings and the findings of preoperative indocyanine green angiography (IA).Methods: Two specimens were obtained during CNV excision associated with PCV. PCV tissue was excised with the CNV. The specimens were examined by light microscopy.Results: In one case, IA revealed polypoidal lesions exhibiting hyperfluorescence in both the early and the late phase, and in the affected area, abnormally dilated vessels were identified histologically underneath relatively healthy retinal pigment epithelium (RPE). In the other case, the polypoidal lesions seen on IA showed early hyperfluorescence and late isofluorescence, and dilated vessels were observed under the RPE; perivascular amorphous material was present. The RPE adhered to the side of the choroid, and there was CNV under the neurosensory retina in both cases. The CNV had numerous vascular lumens, was not surrounded by the RPE, and exhibited few fibrous components.Conclusions: IA findings vary depending on the condition of the RPE located above the PCV and the extent of amorphous material around the PCV. (C) Japanese Ophthalmological Society 2004.