Impact of aging and HIV infection on serologic response to seasonal influenza vaccination
Impact of aging and HIV infection on serologic response to seasonal influenza vaccination
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DOI：
10.1097/qad.0000000000001774
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发表时间：
2018-06-01
期刊：
影响因子：
3.8
通讯作者：
Pahwa, Savita
中科院分区：
文献类型：
--
作者：
Pallikkuth, Suresh;De Armas, Lesley R.;Pahwa, Savita
目的：探讨年龄和HIV感染对流感疫苗应答的影响。设计：评估季节性三价流感疫苗（TIV）对HIV感染（HIV+）和年龄匹配的HIV阴性（HIV-）成人的血清学反应。方法：2013-2016年，对接受抗逆转录病毒治疗的151例病毒学控制的HIV+患者和164例HIV-志愿者（按年龄分为青年（< 40岁）、中年（40-59岁）和老年（50 - 60岁））进行TIV治疗，检测血清抗体对疫苗抗原的反应。结果：90%以上的参与者在预防接种（T0）滴度处于血清保护范围。接种疫苗后，所有参与者的抗体滴度都增加了，但在3-4周时，HIV-组对单个或所有三种疫苗抗原的分类疫苗应答频率高于HIV+组，在年轻年龄组中表现出最大的差异。在三种TIV疫苗株中，T2对H3N2的抗体反应最弱，对H1N1和B抗原的抗体反应主要。在年龄组中，老年人的H1N1和B的滴度最低，有证据表明，在具有B抗原抗体的HIV+人群中存在与年龄相关的相互作用。结论：与HIV-成人相比，HIV+年轻人中疫苗无应答的频率更高，并且在HIV+人群中观察到的与年龄相关的B抗原相互作用支持了控制HIV感染中过早免疫衰老的概念。可考虑对所有年龄的艾滋病毒阳性成年人接种推荐用于健康老年人的高效流感疫苗。版权所有2018威科集团有限公司版权所有。
Objective: To determine influence of age and HIV infection on influenza vaccine responses.Design: Evaluate serologic response to seasonal trivalent influenza vaccine (TIV) as the immunologic outcome in HIV-infected (HIV+) and age-matched HIV negative (HIV-) adults.Methods: During 2013-2016, 151 virologically controlled HIV+ individuals on anti-retroviral therapy and 164 HIV- volunteers grouped by age as young (< 40 years), middle aged (40-59 years) and old (>60 years) were administered TIV and investigated for serum antibody response to vaccine antigens.Results: At prevaccination (T0) titers were in seroprotective range in more than 90% of participants. Antibody titers increased in all participants postvaccination but frequency of classified vaccine responders to individual or all three vaccine antigens at 3-4 weeks was higher in HIV- than HIV+ adults with the greatest differences manifesting in the young age group. Of the three vaccine strains in TIV, antibody responses at T2 were weakest against H3N2 with those to H1N1 and B antigens dominating. Among the age groups, the titers for H1N1 and B were lowest in old age, with evidence of an age-associated interaction in HIV+ persons with antibody to B antigen.Conclusion: Greater frequencies of vaccine nonresponders are seen in HIV+ young compared with HIV- adults and the observed age-associated interaction for B antigen in HIV+ persons are supportive of the concept of premature immune senescence in controlled HIV infection. High-potency influenza vaccination recommended for healthy aging could be considered for HIV+ adults of all ages. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.