Breath biomarkers associated withnontuberculosis mycobacteriadisease status in persons with cystic fibrosis: a pilot study.
Breath biomarkers associated withnontuberculosis mycobacteriadisease status in persons with cystic fibrosis: a pilot study.
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与囊性纤维化患者非结核分枝杆菌疾病状态相关的呼吸生物标志物：一项初步研究。
DOI：
10.1088/1752-7163/ac6bb6
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发表时间：
2022
影响因子：
3.8
通讯作者：
Hill,JaneE
中科院分区：
文献类型：
--
作者：
Mani-Varnosfaderani,Ahmad;Gao,Antao;Poch,KatieR;Caceres,SilviaM;Nick,JerryA;Hill,JaneE
由分枝杆菌引起的肺部感染在人群中引起显著的死亡率和发病率。诊断分枝杆菌感染具有挑战性。感染可导致活动性疾病或保持惰性，临床后果很小。在患有肺非结核分枝杆菌（PNTM）的患者中，感染的鉴定和疾病的诊断可能需要数月至数年。我们以前的研究表明，呼出气样本中的挥发性分子对检测活动性肺结核具有潜在的诊断能力。肺结核感染。在此，我们证明了在囊性纤维化（PwCF）患者的呼吸中检测PNTM疾病状态的能力。我们初步鉴定了17种挥发性分子，这些分子可以区分活动性NTM疾病（n= 6）、惰性患者（n= 3）和从未培养过NTM的患者（n= 2）。研究结果表明，在更大的PwCF队列中，呼吸生物标志物作为诊断NTM疾病的非侵入性和非培养依赖性工具的进一步确认是必要的
Pulmonary infections caused by mycobacteria cause significant mortality and morbidity in the human population. Diagnosing mycobacterial infections is challenging. An infection can lead to active disease or remain indolent with little clinical consequence. In patients with pulmonary nontuberculosis mycobacteria (PNTM) identification of infection and diagnosis of disease can take months to years. Our previous studies showed the potential diagnostic power of volatile molecules in the exhaled breath samples to detect active pulmonary M. tuberculosis infection. Herein, we demonstrate the ability to detect the disease status of PNTM in the breath of persons with cystic fibrosis (PwCF). We putatively identified 17 volatile molecules that could discriminate between active-NTM disease (n= 6), indolent patients (n= 3), and those patients who have never cultured an NTM (n= 2). The results suggest that further confirmation of the breath biomarkers as a non-invasive and culture-independent tool for diagnosis of NTM disease in a larger cohort of PwCF is warranted