HLA-B27 HOMOZYGOSITY IN ANKYLOSING-SPONDYLITIS - RELATIONSHIP TO RISK AND SEVERITY
HLA-B27 HOMOZYGOSITY IN ANKYLOSING-SPONDYLITIS - RELATIONSHIP TO RISK AND SEVERITY
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DOI：
10.1111/j.1399-0039.1978.tb01280.x
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发表时间：
1978-01-01
期刊：
影响因子：
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通讯作者：
STEINBERG, AG
中科院分区：
文献类型：
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作者：
KHAN, MA;KUSHNER, I;STEINBERG, AG
在58例b27阳性的强直性脊柱炎（AS）患者中，观察到的HLA-B27表观纯合子频率（15.5%）显著高于预期的预期频率（4.2%）（P < 0.0005）。对文献的搜索发现了另外4项研究，其中每一项的表观纯合子频率都比预期的要高。这些分析表明，B27纯合子比B27杂合子更容易发生AS。AS的临床特征比较显示，杂合子和表观纯合子之间没有差异，只是后者累及周围关节的频率更高。
The observed frequency of apparent homozygous for HLA-B27 (15.5%) was significantly greater than the estimated expected frequency (4.2%) among 58 B27-positive Caucasian patients with ankylosing spondylitis (AS) (P < 0.0005). A search of the literature uncovered 4 other studies in each of which the frequency of apparent homozygotes was shown to be greater than expected. These analyses indicated that B27 homozygotes are more susceptible to developing AS than are B27 heterozygotes. Comparison of the clinical features of AS showed no differences between heterozygotes and apparent homozygotes except for a higher frequency of involvement of peripheral joints in the latter group.