Poor response inhibition as a predictor of problem drinking and illicit drug use in adolescents at risk for alcoholism and other substance use disorders
Poor response inhibition as a predictor of problem drinking and illicit drug use in adolescents at risk for alcoholism and other substance use disorders
复制标题
DOI：
10.1097/01.chi.0000199028.76452.a9
复制
发表时间：
2006-04-01
影响因子：
13.3
通讯作者：
Zucker, RA
中科院分区：
文献类型：
--
作者：
Nigg, JT;Wong, MM;Zucker, RA
目的：评价执行功能的预测能力，特别是反应抑制，与酒精相关的问题和青少年非法药物使用。方法：来自一项纵向高风险研究的275个家庭的498名儿童在青春期早期和晚期完成了执行功能测量，并在多个时间点（包括青春期晚期（15-17岁））完成了终生饮酒和药物相关评级。在儿童早期（3-5岁）、儿童中期和青春期获得了注意力缺陷/多动障碍和品行障碍的多信息测量。结果如下：在多水平模型中，不良反应抑制预测总的酒精相关问题，使用非法药物的数量，酒精和药物使用共病（但不是药物相关问题的数量），独立于10，父母酗酒和反社会人格障碍，儿童注意力缺陷/多动障碍和行为症状，或年龄。多变量模型解释了8%至20%的结果评分的剩余方差。反应抑制的增量预测能力是适度的，解释了大多数结果中约1%的方差，但在最高风险家庭中问题结果的剩余方差超过9%。其他测量的执行功能没有独立预测物质使用发作。结论：酒精中毒和其他药物风险的模型，调用执行功能可能会受益于指定的反应抑制作为一个增量组件。
Objective: To evaluate the predictive power of executive functions, in particular, response inhibition, in relation to alcohol-related problems and illicit drug use in adolescence. Method: A total of 498 children from 275 families from a longitudinal high-risk study completed executive function measures in early and late adolescence and lifetime drinking and drug-related ratings at multiple time points including late adolescence (ages 15-17). Multi-informant measures of attention-deficit/hyperactivity disorder and conduct disorder were obtained in early childhood (ages 3-5), middle childhood, and adolescence. Results: In multilevel models, poor response inhibition predicted aggregate alcohol-related problems, the number of illicit drugs used, and comorbid alcohol and drug use (but not the number of drug-related problems), independently of 10, parental alcoholism and antisocial personality disorder, child attention-deficit/hyperactivity disorder and conduct symptoms, or age. Multivariate models explained 8% to 20% of residual variance in outcome scores. The incremental predictive power of response inhibition was modest, explaining about 1% of the variance in most outcomes, but more than 9% of the residual variance in problem outcomes within the highest risk families. Other measured executive functions did not independently predict substance use onset. Conclusion: Models of alcoholism and other drug risks that invoke executive functions may benefit from specifying response inhibition as an incremental component.