Euphohyrisnoids A and B, Two Highly Rearranged Lathyrane Diterpenoids from Euphorbia lathyris.
Euphohyrisnoids A and B, Two Highly Rearranged Lathyrane Diterpenoids from Euphorbia lathyris.
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DOI：
10.1021/acs.orglett.1c03812
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发表时间：
2021-11
期刊：
影响因子：
5.2
通讯作者：
Dong Huang;Yue-Hua Pan;Fang-yu Yuan;Wei Li;Xue-long Yan;Ming-Feng Zou;G. Tang;Sheng Yin
中科院分区：
文献类型：
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作者：
Dong Huang;Yue-Hua Pan;Fang-yu Yuan;Wei Li;Xue-long Yan;Ming-Feng Zou;G. Tang;Sheng Yin
Euphhyrisnoids A (1) 和 B (2) 是两种高度重排的山楂二萜类化合物，分别具有独特的四环[10.2.2.01,10.03,7]十六烷和三环[8.4.1.03,7]十五烷骨架，是从山黧豆种子中分离出来的。它们的结构通过详细的光谱分析确定，并通过单晶 X 射线衍射进一步证实。 1 通过在早期延迟细胞分化来显着抑制 3T3-L1 脂肪细胞的脂肪生成。
Euphohyrisnoids A (1) and B (2), two highly rearranged lathyrane diterpenoids featuring a unique tetracyclo[10.2.2.01,10.03,7]cetane and tricyclo[8.4.1.03,7]pentadecane skeleton, respectively, were isolated from the seeds of Euphorbia lathyris. Their structures were determined by detailed spectroscopic analysis and were further confirmed by single-crystal X-ray diffraction. 1 significantly inhibited adipogenesis in 3T3-L1 adipocytes by retarding cell differentiation at the early stage.