Sensitive Determination of Dopamine and Uric Acid by the Use of a Glassy Carbon Electrode Modified with Poly(3-methylthiophene)/Gold Nanoparticle Composites
Sensitive Determination of Dopamine and Uric Acid by the Use of a Glassy Carbon Electrode Modified with Poly(3-methylthiophene)/Gold Nanoparticle Composites
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聚(3-甲基噻吩)/金纳米粒子复合材料修饰玻碳电极灵敏测定多巴胺和尿酸
DOI：
10.2116/analsci.24.1563
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发表时间：
2008-12-01
影响因子：
1.6
通讯作者：
Wang, Lun
中科院分区：
文献类型：
--
作者：
Huang, Xue;Li, Yongxin;Wang, Lun
将一种新型的纳米复合材料聚3-甲基噻吩（P3 MT）/金纳米粒子（AuNPs）成功地沉积在玻碳电极表面。采用场发射扫描电子显微镜（FE-SEM）和电化学技术对修饰电极进行了表征。结果表明，纳米金颗粒均匀地嵌入到P3 MT层中，形成了多孔的三维结构。该修饰电极对抗坏血酸（AA）、多巴胺（DA）和尿酸（UA）的氧化表现出良好的电催化活性，AA、DA和UA的重叠阳极峰完全分为3个清晰的伏安峰。进一步的研究表明，DA和UA的浓度分别在1.0 × 10-^6 ~ 3.5 × 10-^5 mol L^-1和1.0 × 10-^6 ~ 3.2 × 10-^5 mol L^-1范围内与峰电流呈线性关系。DA和UA的检测限分别为2.4 × 10^-7 mol L^-1和1.7 × 10^-7 mol L^-1。将该方法应用于真实的样品的检测，结果令人满意。
A kind of novel nanocomposites, poly(3-methylthiophene) (P3MT)/gold nanoparticles (AuNPs), were successfully deposited onto the surface of a glassy carbon electrode. A field emission scanning electron microscope (FE-SEM) and electrochemical techniques were used for characterizing this modified electrode. The results showed that the AuNPs were inserted into a P3MT layer uniformly, and formed a porous 3D structure. This modified electrode showed excellent electrocatalytic activity towards the oxidation of ascorbic acid (AA), dopamine (DA) and uric acid (UA); the overlapping anodic peaks of AA, DA and UA were completely divided into three well-defined voltammetric peaks. A further study showed that there existed a linear relationship between the peak current and the concentration of DA in the range of 1.0 × 10-^6 to 3.5 × 10-^5 mol L^-1, and UA in the range of 1.0 × 10-^6 to 3.2 × 10^5 mol L^1. The detection limits were 2.4 × 10^-7 mol L^-1 for DA and 1.7 × 10^-7 mol L^-1 for UA. This proposed method was applied to the detection of real samples, and the results were satisfactory.