The prevalence of neuropsychiatric syndromes in systemic lupus erythematosus
The prevalence of neuropsychiatric syndromes in systemic lupus erythematosus
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DOI：
10.1212/wnl.57.3.496
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发表时间：
2001-08-14
期刊：
影响因子：
9.9
通讯作者：
Hietaharju, A
中科院分区：
文献类型：
--
作者：
Ainiala, H;Loukkola, J;Hietaharju, A
目的：描述芬兰系统性红斑狼疮（SLE）患者人群中神经精神（NP）综合征的患病率，并根据最近制定的美国风湿病学会（ACR）命名法和NPSLE病例定义对其进行分类。方法：以人口为基础的横断面研究，覆盖44万人。在地区医院的计算机数据库中，共发现了58例确诊为SLE的患者，年龄在16至65岁之间。其中46人（79%）同意参加。各种NP综合征的诊断是基于临床印象（H.A.）以下是病史、检查、病历回顾和神经心理学测试。结果：42例患者（91%）至少有一种NP综合征。最常见的表现是认知功能障碍（n = 37; 81%），其次是头痛（n = 25; 54%）和情绪障碍（n = 20; 43%）。当排除轻度NP综合征（轻度认知缺陷、头痛、轻度抑郁、焦虑、神经肌电图阴性多发性神经病）时，NPSLE的患病率降至46%。结论：根据ACR命名法，在以人群为基础的SLE患者样本中，NP表现的患病率很高。大多数NP综合征被归类为轻微的，如果他们被排除在外，46%，患病率NPSLE将略低于估计在以前的研究。
Objective: To describe the prevalence of neuropsychiatric (NP) syndromes in a Finnish population of patients with systemic lupus erythematosus (SLE) and to classify them according to the recently developed American College of Rheumatology (ACR) nomenclature and case definitions for NPSLE. Methods: Cross-sectional, population-based study covering an area with 440,000 people. A total of 58 patients with a definite diagnosis of SLE and aged 16 to 65 years were found in the computerized database of the area hospitals. Of these, 46 (79%) agreed to participate. The diagnosis of various NP syndromes was based on clinical impression (H.A.) following history, examination, review of medical records, and neuropsychologic testing. Results: At least one NP syndrome was identified in 42 patients (91%). The most frequent manifestation was cognitive dysfunction (n = 37; 81%), followed by headache (n = 25; 54%) and mood disorder (n = 20; 43%). When mild NP syndromes (mild cognitive deficit, headache, mild depression, anxiety, electroneuromyography-negative polyneuropathy) were excluded, the prevalence of NPSLE dropped to 46%. Conclusions: According to the ACR nomenclature, there is a high prevalence of NP manifestations in a population-based sample of patients with SLE. Most NP syndromes were classified as minor; if they were excluded, the 46%, prevalence of NPSLE would be slightly less than estimated in previous studies.