Inositol-1,4,5-Trisphosphate
Inositol-1,4,5-Trisphosphate
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肌醇-1,4,5-三磷酸
DOI：
10.1007/978-94-011-0679-5_93
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发表时间：
1995
期刊：
影响因子：
7.7
通讯作者：
J. Wilson
中科院分区：
文献类型：
--
作者：
J. Wilson
许多促分泌素、激素和神经递质的作用机制涉及细胞内钙水平的快速增加。钙是通过三磷酸肌醇(IP3)的作用从细胞内的囊泡中释放出来的。IP3是存在于细胞膜上的磷脂酰肌醇-4，5-二磷酸被同样存在于细胞膜上的激动剂激活的磷脂酶C切割而成的胞内第二信使。IP3是短暂的，在重新结合到细胞膜之前，在细胞内被迅速去磷酸化成二和单衍生物。
Many secretagogues, hormones and neuro-transmitters produce their effects by a mechanism that involves a rapid increase in intracellular calcium levels. The calcium is released from intracellular vesicular stores by the action of inositol trisphosphate (IP3). IP3 is a cytosolic second messenger cleaved from phosphatidyl-inositol-4,5-diphosphate present in the cell membrane by the agonist-activated enzyme phospholipase C also resident in the membrane. IP3 is short lived, being quickly dephosphorylated within the cell to di- and mono-derivatives before being reincorporated into the cell membrane.