Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia.
Genetic variation at the synaptic vesicle gene SV2A is associated with schizophrenia.
复制标题
突触小泡基因 SV2A 的遗传变异与精神分裂症有关。
DOI：
10.1016/j.schres.2012.08.027
复制
发表时间：
2012
影响因子：
4.5
通讯作者：
Rujescu
中科院分区：
文献类型：
--
作者：
Mattheisen,Manuel;Mühleisen,ThomasW;Strohmaier,Jana;Treutlein,Jens;Nenadic,Igor;Alblas,Margrieta;Meier,Sandra;Degenhardt,Franziska;Herms,Stefan;Hoffmann,Per;Witt,StephanieH;Giegling,Ina;Sauer,Heinrich;Schulze,ThomasG;Rujescu
来自药理学和动物研究的证据表明突触囊泡糖蛋白2A基因（SV2A）在精神分裂症易感性中可能发挥作用。为了系统地测试SV2A基因区域中所有常见变异与精神分裂症的关联，我们使用了基于HapMap的单倍型标记方法，并在794名患者和843名对照中测试了5个SNP。SNP rs15931显示与精神分裂症相关的证据，并在2581人的独立样本中进行了随访（总体p值=0.0042，OR=0.779）。我们在德国人群中的研究在遗传水平上提供了SV2A基因区域参与精神分裂症的证据。
Convergent evidence from pharmacological and animal studies suggests a possible role for the synaptic vesicle glycoprotein 2A gene (SV2A) in schizophrenia susceptibility. To test systematically all common variants in the SV2A gene region for an association with schizophrenia, we used a HapMap-based haplotype tagging approach and tested five SNPs in 794 patients and 843 controls. The SNP rs15931 showed evidence for an association with schizophrenia and was followed-up in an independent sample of 2581 individuals (overall p-value=0.0042, OR=0.779). Our study in the German population provides evidence, at a genetic level, for the involvement of the SV2A gene region in schizophrenia.