Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials
Comparative efficacy of anticoccidials under the conditions of commercial broiler production and in battery trials
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DOI：
10.1016/s0304-4017(97)00203-3
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发表时间：
1998-04-15
影响因子：
2.6
通讯作者：
Rommel, M
中科院分区：
文献类型：
--
作者：
Daugschies, A;Gasslein, U;Rommel, M
球虫是从一个有疑似抗药性病史的商业肉鸡养殖场分离出来的。艾美耳球虫Eimeria spp.对推荐剂量水平的抗球虫药物尼加拉瓜巴津(NIC)、那拉辛(NAR)、卤代呋喃酮(HAL)、盐霉素(SAL)、甲氧氯品醇(MET)和莫能菌素(MON)进行了三次电池试验(B1、B2、B3)，对应于三个商业肉鸡饲养时期(F1、F2、F3)的田间研究。在F1(NIC/MON)和F2(MET/MON)中执行穿梭程序，而在F3中仅使用SAL。在F1指示鸡中分离到艾美耳球虫和柔嫩艾美耳球虫，而在F2和F3中仅检出艾美耳球虫。在试验B1中，来自F1的分离株被鉴定为对HAL具有抗性，对F1中使用的两种药物NIC和MON具有部分抗性。在用MET取代发酵剂中的NIC后，F2分离株对电离团没有抗性(试验B2)，但对HAL仍有部分抗性。由于SAL是B1和B2中最有效的药物，因此该药物仅在F3中应用。除了对HAL的耐药性外，在来自F3的分离株中没有发现对任何其他测试的抗球虫药物的耐药性。SAL在田间有效地控制了球虫病，F3的产量最高。这项研究表明，在商业肉鸡生产条件下，电池试验对抗球虫药物的疗效具有良好的预测价值。(C)1998年爱思唯尔科学公司。
Coccidia were isolated from a commercial broiler farm with a history of suspected drug resistance. The sensitivity profiles of the Eimeria spp. isolates against the anticoccidial drugs nicarbazin (NIC), narasin (NAR), halofuginone (HAL), salinomycin (SAL), meticlorpindol plus methylbenzoquate (MET), and monensin (MON) at the recommended dose levels were followed in three battery trials (B1, B2, B3) corresponding to a field study over three periods of commercial broiler keeping (F1, F2, F3). Shuttle programs were performed in F1 (NIC/MON) and in F2 (MET/MON) while only SAL was used in F3. Eimeria acervulina and E. tenella were isolated from indicator birds in F1 while only E. acervulina could be found during F2 and F3. In trial B1 the isolate from F1 was identified as resistant against HAL and partly resistant against NIC and MON, the two drugs that were used in F1. Following the replacement of NIC in the starter feed by MET the respective isolate from F2 showed no resistance against ionophores (trial B2) while partial resistance against HAL was still present. Since SAL was the most efficient drug in B1 and B2 only this drug was applied in F3. Apart from a resistance against HAL no resistance against any of the other tested anticoccidials was found in the isolate from F3. SAL controlled coccidiosis efficiently in the field and best productivity was recorded in F3. This study shows that battery trials have a good predictive value in respect to the efficacy of anticoccidials under the conditions of commercial broiler production. (C) 1998 Elsevier Science B.V.