A biomimetic nanoenzyme for starvation therapy enhanced photothermal and chemodynamic tumor therapy
A biomimetic nanoenzyme for starvation therapy enhanced photothermal and chemodynamic tumor therapy
复制标题
用于饥饿疗法的仿生纳米酶增强光热和化学动力学肿瘤治疗
DOI：
10.1039/d0nr05097k
复制
发表时间：
2020-12-07
期刊：
影响因子：
6.7
通讯作者：
Zhang, Haiyuan
中科院分区：
文献类型：
--
作者：
Xu, Keqiang;Wu, Xiaqing;Zhang, Haiyuan
Photothermal therapy (PTT) and chemodynamic therapy (CDT) are promising therapeutic modalities with high specificity, however, a single therapeutic modality cannot maximize therapeutic efficacy. In the present study, glucose oxidase (GOx) was decorated on N-doped carbon (NC) nanoparticles (NPs) as a biomimetic nanoenzyme (NC@GOx NPs), which could promote starvation therapy enhanced PTT and CDT against tumors. GOx could decompose to cut off the supply of energy and nutrients, inducing starvation therapy, which further lowered adenosine triphosphate (ATP) levels, inducing downregulated heat shock proteins and creating a more suitable microenvironment for improving PTT efficacy. Meanwhile, the generated endogenous hydrogen peroxide (H2O2) could be converted into hydroxyl radicals to attack cancer cells. In fact, in vitro and in vivo experiments demonstrated that NC@GOx NPs could effectively kill cancer cells and eliminate tumors. This design provides a strategy for synergistic cancer therapy by using biomimetic nanoenzymes.
