Time of cell origin and cell death in the avian dorsal motor nucleus of the vagus
Time of cell origin and cell death in the avian dorsal motor nucleus of the vagus
复制标题
禽迷走神经背运动核细胞起源和细胞死亡的时间
DOI：
10.1002/cne.901990110
复制
发表时间：
1981
影响因子：
2.5
通讯作者：
L. L. Wright
中科院分区：
文献类型：
--
作者：
L. L. Wright
本文研究了鸡胚、幼雏和成年鸡迷走神经背侧运动核的细胞增殖停止和细胞死亡。大多数细胞（94%）在孵育的第2天和第3天完成其最终的DNA合成。在增殖的停止中存在尾吻梯度，尾侧细胞比中间和吻侧细胞稍微提前退出细胞周期。背运动核中的细胞死亡导致在第8天和第12天之间损失21%的细胞，并且通过孵化损失37%的细胞。在细胞死亡方面也存在尾吻梯度，在吻侧区域发生更多延迟和逐渐的细胞丢失。细胞死亡的时间和空间模式可能与核的几个靶点的非同步神经支配有关。
Cessation of cell proliferation and cell death were studied in the dorsal motor nucleus of the vagus of the chick embryo, hatchling, and adult. Most of the cells comprising the nucleus (94%) complete their final DNA synthesis on days 2 and 3 of incubation. There is a caudo‐rostral gradient in the cessation of proliferation, with the caudalmost cells withdrawing from the cell cycle slightly in advance of the middle and rostral cells. Cell death in the dorsal motor nucleus results in a 21% loss of cells between days 8 and 12, and 37% loss by hatching. A caudo‐rostral gradient was also present with respect to cell death, with more delayed and gradual cell loss occurring in the rostral region. The timing and spatial pattern of cell death may be related to the asynchronous innervation of the several targets of the nucleus.