Prenatal stress and developmental programming of human health and disease risk: concepts and integration of empirical findings.
Prenatal stress and developmental programming of human health and disease risk: concepts and integration of empirical findings.
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DOI：
10.1097/med.0b013e3283405921
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Wadhwa PD
中科院分区：
文献类型：
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作者：
Entringer S;Buss C;Wadhwa PD
健康与疾病易感性的发育起源这一概念正迅速引起关注并日益凸显，它是理解许多造成重大疾病负担的复杂常见疾病病因的一种补充方法；然而，仍有几个重要的问题有待解决，特别是在人类的背景下。
在这篇综述中，我们阐述了其中的一些问题，主要回顾了我们自己近期关于产前应激和应激生物学的研究经验证据，并讨论了可能构成产前应激对发育中的人类胚胎和胎儿短期及长期影响的基础并介导这些影响的假定的母体 - 胎盘 - 胎儿内分泌和免疫/炎症候选机制，特别关注身体成分、代谢功能和肥胖风险。
我们结合纵向、重复测量时间序列分析的现有最先进的统计建模方法，讨论了对研究和临床实践的启示，并总结了用于表征胎儿、新生儿、婴儿和儿童发育及健康相关过程的非侵入性方法的最新进展，这些进展现在为探索和揭示人类健康与疾病的发育起源提供了前所未有的机会。
The concept of the developmental origins of health and disease susceptibility is rapidly attracting interest and gaining prominence as a complementary approach to understanding the causation of many complex common disorders that confer a major burden of disease; however several important issues and questions remain to be addressed, particularly in the context of humans. In this review we enunciate some of these questions and issues, review empirical evidence primarily from our own recent studies on prenatal stress and stress biology, and discuss putative maternal–placental–fetal endocrine and immune/inflammatory candidate mechanisms that may underlie and mediate short-term and long-term effects of prenatal stress on the developing human embryo and fetus, with a specific focus on body composition, metabolic function, and obesity risk. The implications for research and clinical practice are discussed with a summary of recent advances in noninvasive methods to characterize fetal, newborn, infant, and child developmental and health-related processes that, when coupled with available state-of-the-art statistical modeling approaches for longitudinal, repeated measures time series analysis, now afford unprecedented opportunities to explore and uncover the developmental origins of human health and disease.