Ethanol exposure during development reduces resident aggression and testosterone in rats
Ethanol exposure during development reduces resident aggression and testosterone in rats
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DOI：
10.1016/j.physbeh.2005.10.005
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发表时间：
2006-02-28
影响因子：
2.9
通讯作者：
Kelly, SJ
中科院分区：
文献类型：
--
作者：
Lugo, JN;Marino, MD;Kelly, SJ
在发育过程中暴露于乙醇已被证明会改变人类的社会行为，但缺陷的范围尚不清楚。使用胎儿酒精谱系障碍的动物模型，在成年大鼠中检查雄性之间的攻击和睾酮水平。大鼠在整个产前期间和出生后第2天至第10天暴露于乙醇。通过胃内插管给予乙醇。另外两组包括未处理对照组和插管对照组，插管对照组暴露于给药程序但不暴露于乙醇。在三种不同的居住条件下，对实验居民和入侵者的进攻性和防御性攻击进行了检查：（1）与另一只雄性，（2）与怀孕的雌性，（3）与实验动物的雌性和幼崽。当与雌性和窝一起饲养时，与相同条件下的对照组相比，暴露于乙醇的大鼠表现出攻击性降低。在同样的条件下，非实验性入侵者的防御性攻击也减少了。在任何住房条件下，各组之间的非攻击性社会行为的持续时间没有差异。与对照组相比，暴露于乙醇的大鼠中的替吉奥水平降低。总之，在产前和产后时期的乙醇暴露减少了攻击性行为的条件下，攻击性行为是正常的。这种减少可能与较低的睾酮水平有关。(c)2005年爱思唯尔公司All rights reserved.
Ethanol exposure during development has been shown to alter social behaviors in people, but the range of deficits is not clear. Using an animal model of Fetal Alcohol Spectrum Disorders, inter-male aggression and testosterone levels were examined in adult rats. Rats were exposed to ethanol during the entire prenatal period and from postnatal day 2 through 10. Ethanol was administered via intragastric intubation. Two other groups consisted of a nontreated control and an intubated control group that was exposed to the administration procedures but not ethanol. Both offensive and defensive aggression were examined in experimental residents and intruders under three different housing conditions for the resident mates: (1) with another male, (2) with a pregnant female, and (3) with a female and litter fathered by the experimental animal. When housed with a female and litter, ethanol-exposed rats displayed reduced offensive aggression compared to control groups under the same condition. Defensive aggression in the non-experimental intruders was reduced in this same condition. There were no differences in duration of non-aggressive social behaviors among the groups in any of the housing conditions. Testosterone levels were reduced in ethanol-exposed rats compared to controls. In summary, ethanol exposure over the combined prenatal and postnatal periods reduces aggressive behavior in a condition where aggressive behavior is normally seen. This reduction may be related to lower testosterone levels. (c) 2005 Elsevier Inc. All rights reserved.