Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe.
Antiretroviral therapy outcomes among adolescents and youth in rural Zimbabwe.
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DOI：
10.1371/journal.pone.0052856
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Munyaradzi D
中科院分区：
文献类型：
--
作者：
Bygrave H;Mtangirwa J;Ncube K;Ford N;Kranzer K;Munyaradzi D
据估计，全世界约有200万青少年和300万青年感染艾滋病毒。与成年人相比，这一组的抗逆转录病毒治疗结果似乎更差。我们报告了2005年至2008年间在津巴布韦农村地区开始接受抗逆转录病毒治疗的10-30岁患者的抗逆转录病毒治疗结果。该队列被分为4个年龄组：10-15岁（青少年）、15.1-19岁（青少年）、19.1-24岁（年轻人）和24.1-29.9岁（老年人）。生存分析用于估计按年龄组分层的死亡率和随访损失。终点为从抗逆转录病毒治疗开始到死亡或失去随访的时间。在转移日期或研究结束时（2008年12月31日）对持续治疗患者的随访进行审查。采用性别校正Cox比例风险模型估计不同年龄组的风险比。898例患者纳入分析；抗逆转录病毒治疗的中位持续时间为468天。与青少年相比，成人的死亡风险最高（aHR 2.25, 95%CI 1.17-4.35）。与青少年相比，年轻人和青少年失去随访的风险高2-3倍。当估计消耗合并随访损失和死亡的风险时，年轻人的风险最高（aHR 2.70, 95%CI 1.62-4.52）。这项研究强调了为青少年和年轻人提供适应的依从性支持和服务提供模式的必要性。
Around 2 million adolescents and 3 million youth are estimated to be living with HIV worldwide. Antiretroviral outcomes for this group appear to be worse compared to adults. We report antiretroviral therapy outcomes from a rural setting in Zimbabwe among patients aged 10–30 years who were initiated on ART between 2005 and 2008. The cohort was stratified into four age groups: 10–15 (young adolescents) 15.1–19 years (adolescents), 19.1–24 years (young adults) and 24.1–29.9 years (older adults). Survival analysis was used to estimate rates of deaths and loss to follow-up stratified by age group. Endpoints were time from ART initiation to death or loss to follow-up. Follow-up of patients on continuous therapy was censored at date of transfer, or study end (31 December 2008). Sex-adjusted Cox proportional hazards models were used to estimate hazard ratios for different age groups. 898 patients were included in the analysis; median duration on ART was 468 days. The risk of death were highest in adults compared to young adolescents (aHR 2.25, 95%CI 1.17–4.35). Young adults and adolescents had a 2–3 times higher risk of loss to follow-up compared to young adolescents. When estimating the risk of attrition combining loss to follow-up and death, young adults had the highest risk (aHR 2.70, 95%CI 1.62–4.52). This study highlights the need for adapted adherence support and service delivery models for both adolescents and young adults.
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影响因子：
7.6
作者：
Belzer, ME;Fuchs, DN;Tucker, DJ
通讯作者：
Tucker, DJ
DOI：
10.2471/blt.07.050120
发表时间：
2008-12-01
期刊：
Bulletin of the World Health Organization: International Journal of Public Health
影响因子：
--
作者：
Charles, Macarthur;Noel, Francine;Fitzgerald, Daniel W
通讯作者：
Fitzgerald, Daniel W
影响因子：
3.7
作者：
Van Cutsem G;Ford N;Hildebrand K;Goemaere E;Mathee S;Abrahams M;Coetzee D;Boulle A
通讯作者：
Boulle A
影响因子：
3.6
作者：
Cremin, I.;Mushati, P.;Gregson, S.
通讯作者：
Gregson, S.
影响因子：
7.2
作者：
Knol, Mirjam J.;Janssen, Kristel J. M.;Geerlings, Mirjam I.
通讯作者：
Geerlings, Mirjam I.