CHLOROQUINE MYOPATHY
CHLOROQUINE MYOPATHY
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DOI：
10.1136/jnnp.29.4.331
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发表时间：
1966-01-01
影响因子：
11
通讯作者：
FERRIER, TM
中科院分区：
文献类型：
--
作者：
EADIE, MJ;FERRIER, TM
临床、生化、肌电图和组织学结果表明，患者服用氯喹6个月后出现肌病。症状的出现、停药后的恢复和可逆性角膜变化之间的关系进一步证明氯喹是肌病的原因。肌肉空泡改变是氯喹引起的病变的特征。这些都伴随着糖原积累。这表明该药物可能通过抑制参与糖原代谢的酶而损伤肌肉。
Clinical, biochemi-cal, electromyographic and histological findings indicated a myopathy in a patient who had been receiving chloroquine for 6 mo. The relation of the onset of symptoms, the recovery after this drug was stopped and the reversible corneal changes gave added evidence that chloroquine was the cause of the myopathy. Vacuolar changes in muscle are characteristic of lesions produced by chloroquine. These have been accompanied by glycogen accumulations. This suggests that the drug may injure the muscle by inhibiting enzymes involved in glycogen metabolism.