Anticardiolipin antibodies and autoimmune diseases.
Anticardiolipin antibodies and autoimmune diseases.
复制标题
抗心磷脂抗体和自身免疫性疾病。
DOI：
10.1097/00002281-198901020-00015
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发表时间：
1989
影响因子：
5.1
通讯作者：
Harris En
中科院分区：
文献类型：
--
作者：
Harris En
抗心磷脂抗体确实是20世纪80年代的一个主题。[1]诚然，我们几十年来就知道梅毒可以诱导与心磷脂结合的抗体，这种结合通过凝集或补体结合试验得到最好的证明(Catterall，in Walker，ed.第九届先进医学学术研讨会。皮特曼，1977，第97-111页)。我们还知道，患有各种自身免疫性疾病的患者有时梅毒检测呈假阳性，这表明抗心磷脂抗体是这些疾病产生的一系列非器官特异性自身抗体之一(摩尔和莫尔，JAMA1952,150.467-473年)。然而，在1983年，随着抗心磷脂抗体固相放射免疫检测的发展(Harris等人)。Lancet 1983，II：1211-1214)，我们可能偶然发现了一组针对心磷脂和其他阴离子磷脂的“新”自身抗体(Harris等人，/临床实验室免疫学1985年，17：155-162)，更重要的是，现在似乎这些抗体的一亚组与血栓形成、复发性胎儿丢失和血小板减少有关，特别是当抗体滴度高和Ig G同型时(Harris等人，Arch Intern Med 1986,1462153-2159)，通过固相免疫分析检测的抗心磷脂抗体很可能是结合心磷脂和其他磷脂分子的抗体家族的一部分。这个抗体家族最好的名称是“抗磷脂抗体”(哈里斯，临床大黄病1985年，11591-596年)。除了系统性红斑狼疮和梅毒等疾病外，这些抗体还可在各种感染性、自身免疫性和药物诱导性疾病中诱导，以及在其他健康个体中诱导。
Anticardiolipin antibodies are truly a subject of the 1980s.[1] Admittedly, we have known for several decades that syphilis can induce antibodies that bind cardiolipin, this binding being demonstrated best by agglutination or complement fixation tests (Catterall, in Walker, ed. Ninth Symposium on Advanced lledicine. Pitman, 1977, pp 97–111). We have also known that patients with a variety of autoimmune disorders sometimes have false-positive tests for syphilis, suggesting that anticardiolipin antibodies were one of a spectrum of non-organ-specific autoantibodies produced in these disorders (Moore and Mohr, JAMA 1952, 150.467–473) However, in 1983, with the development of a solidphase radioimmunoassay test for anticardiolipin anti-bodies (Harris et al. Lancet 1983, ii: 1211–1214), we may have stumbled on a somewhat" new" group of autoantibodies specific for cardiolipin and other anionic phospholipids (Harris et al.,/Clin Lab Immunol 1985, 17: 155–162), More importantly, it now appears that a subgroup of these antibodies are associated with an increased risk of thrombosis, recurrent fetal loss, and thrombocytopenia, particularly when antibody titers are high and of the IgG isotype (Harris et al., Arch Intern Med 1986, 1462153–2159)It is likely that anticardiolipin antibodies detected by solid-phase immunoassays are part of a family of antibodies that bind cardiolipin and other phospholipid molecules. This family of antibodies is best designated" antiphospholipid antibodies"(Harris, Clin Rheum Dis 1985, 11591–596). In addition to diseases such as systemic lupus erythematosus and syphilis, these antibodies may be induced in a variety of infectious, autoimmune, and drug-induced disorders, as well as in otherwise healthy individuals.