Chronic antigenic load and apoptosis in immunosenescence
Chronic antigenic load and apoptosis in immunosenescence
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DOI：
10.1016/j.it.2004.11.005
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发表时间：
2005-02-01
影响因子：
16.8
通讯作者：
Franceschi, C
中科院分区：
文献类型：
--
作者：
Ginaldil, L;De Martinis, M;Franceschi, C
免疫系统的细胞经历了两种不同的凋亡过程：免疫细胞特有的激活诱导细胞死亡(AICD)和损伤诱导细胞死亡(DICD)，DICD是一种更普遍的现象，对各种细胞损伤做出反应，主要是氧化代谢副产物。AICD旨在消除抗原刺激导致的克隆性扩增后不必要的淋巴细胞，而DICD在预防肿瘤增殖方面尤为重要。我们假设氧化应激和慢性抗原负荷都严重影响免疫系统，导致淋巴细胞对DICD的易感性降低，并导致致炎状态导致AICD增加。AICD和DICD的这种微妙的重塑推动了免疫衰老，有助于老年人免疫系统的表型和功能特征。
The cells of the immune system undergo two different kinds of apoptotic processes: activation-induced cell death (AICD), peculiar to immune cells, and damage-induced cell death (DICD), a more generalized phenomenon in response to a variety of cellular insults, mainly oxidative metabolism by-products. AICD is geared towards the elimination of unnecessary lymphocytes following clonal expansion that results from antigenic stimulation, whereas DICD is particularly important for preventing the onset of neoplastic proliferation. We hypothesize that both oxidative stress and chronic antigenic load, which impinge heavily on the immune system, induce decreased lymphocyte susceptibility to DICD and a proinflammatory status leading to increased AICD. This subtle remodeling of AICD and DICD drives immunosenescence, contributing to the phenotypic and functional characteristics of the elderly immune system.