Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients.
Thyroid hormone levels in the prefrontal cortex of post-mortem brains of Alzheimer's disease patients.
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DOI：
10.2174/1874609810801030175
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发表时间：
2008-12
影响因子：
--
通讯作者：
Stern RA
中科院分区：
文献类型：
--
作者：
Davis JD;Podolanczuk A;Donahue JE;Stopa E;Hennessey JV;Luo LG;Lim YP;Stern RA
越来越多的证据表明甲状腺状态与阿尔茨海默病（AD）之间可能存在联系，包括TSH水平较高的个体患痴呆症的可能性较高，甲状腺功能减退症患者患AD的风险增加一倍。甲状腺激素调节与AD相关的因素，包括脑中淀粉样前体蛋白的表达，这表明甲状腺激素在AD病理学中可能起作用。本研究是第一个直接评估AD患者脑甲状腺激素水平的研究。采用放射免疫分析法（RIA）测定了病理证实的AD患者（Braak I ~ II期（n=8）、Braak V ~ VI期（n = 8））和无任何原发性神经系统疾病的对照组（n=8）的前额皮质三碘甲状腺原氨酸（T3）和甲状腺素（T4）水平。各组之间的T4水平没有差异。与对照组相比，Braak V-VI期脑中的T3水平显著较低，但Braak I-II期脑中的T3水平与对照组相比无统计学显著差异。结果表明，T4到T3的转换可能会受到影响，在先进的AD，可能是由于脱碘酶活性的改变。AD患者T4向T3转化减少可能与AD病理学和痴呆临床表现相关。
Converging evidence suggests a possible link between thyroid state and Alzheimer’s disease (AD), including a higher probability of dementia in individuals with higher TSH levels and a two-fold risk of AD in patients with hypothyroidism. Thyroid hormones modulate factors associated with AD, including amyloid precursor protein expression in the brain, suggesting a possible role for thyroid hormone in AD pathology. The present study is the first to directly evaluate brain thyroid hormone levels in AD. Triiodothyronine (T3) and thyroxine (T4) levels were measured with radioimmunoassay (RIA) in post-mortem samples of prefrontal cortex of patients with pathologically confirmed AD, including Braak stage I–II (n=8), Braak stage V–VI (n=8), and controls without any primary neurological disease (n=8). T4 levels did not differ between groups. T3 levels were significantly lower in Braak stage V–VI brains relative to controls, but there was no statistically significant difference between T3 levels in Braak stage I–II versus controls. Results suggest that the conversion of T4 to T3 may be affected in advanced AD, perhaps due to alterations in deiodinase activity. Reduced conversion of T4 to T3 in AD may be associated with both AD pathology and the clinical presentation of dementia.