Association between type 2 diabetes and exposure to persistent organic pollutants.
Association between type 2 diabetes and exposure to persistent organic pollutants.
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DOI：
10.2337/dc10-2303
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发表时间：
2011-09
期刊：
影响因子：
16.2
通讯作者：
Kiviranta H
中科院分区：
文献类型：
--
作者：
Airaksinen R;Rantakokko P;Eriksson JG;Blomstedt P;Kajantie E;Kiviranta H
2型糖尿病的发病率在发达国家和发展中国家都在惊人地增加。最近，暴露于持久性有机污染物（POP）已与2型糖尿病的患病率。这项横断面研究的目的是在赫尔辛基出生队列研究中检查2型糖尿病和POP暴露之间的关系。该队列由1934-1944年期间出生于赫尔辛基的8，760人组成，当时全球持久性有机污染物排放量达到峰值。2003年，进行了一次临床检查，包括采集血液样本，以便对血清脂质和持久性有机污染物进行实验室分析。有1 988名参加者的完整考试数据。根据百分位数间隔将每种POP的浓度分为四组，并进行逻辑回归以检查POP类别中的糖尿病患病率，调整性别，年龄，腰围和平均动脉压，并使用最低类别作为参考组。在最高接触氧氯草胺的参与者中，反式-九氯，1，1-二氯-2，2-双-对氯苯基乙烯（p，p '-DDE和多氯联苯153），2型糖尿病的风险是最低暴露个体的1.64-2.24倍（Plin = 0.003-0.050，其中Plin是POP类别之间线性趋势的P值）。在分层分析中，2型糖尿病与氧氯噻嗪和反式九甲草胺之间的关联仍然很显著，并且在超重的参与者中最强。接触2，2 ′，4，4 ′-四溴二苯醚（BDE 47）和2，2 ′，4，4 ′，5，5 ′-六溴二苯醚（BDE 153）与2型糖尿病无关。这项研究证实了2型糖尿病与一般城市人群中仅成年人接触有机氯农药之间的关联。
The prevalence of type 2 diabetes is increasing alarmingly in both developed and developing countries. Recently, exposure to persistent organic pollutants (POPs) has been associated with the prevalence of type 2 diabetes. The purpose of this cross-sectional study is to examine the association between type 2 diabetes and POP exposure in the Helsinki Birth Cohort Study. The cohort consists of 8,760 people born in Helsinki during 1934–1944, before the global POP emission peak. In 2003, a clinical examination was performed, including blood sampling for laboratory analyses of serum lipids and POPs. Complete data from the examination were available for 1,988 participants. The concentrations of each POP were categorized into four groups on the basis of percentile intervals, and logistic regression was performed to examine diabetes prevalence across the POP categories, adjusting for sex, age, waist circumference, and mean arterial pressure and using the lowest category as the reference group. Among the participants with the highest exposure to oxychlordane, trans-nonachlor, 1,1-dichloro-2,2-bis-(p-chlorophenyl)-ethylene (p,p’-DDE, and polychlorinated biphenyl 153, the risk of type 2 diabetes was 1.64–2.24 times higher than that among individuals with the lowest exposure (Plin = 0.003–0.050, where Plin is the P value for linear trend across POP categories). In the stratified analysis, the associations between type 2 diabetes and oxychlordane and trans-nonachlor remained significant and were strongest among the overweight participants. Exposure to 2,2′,4,4′-tetrabromodiphenyl ether (BDE 47) and 2,2′,4,4′,5,5′-hexabromodiphenyl ether (BDE 153) was not associated with type 2 diabetes. This study confirms the association between type 2 diabetes and adult-only exposure to organochlorine pesticides in a general urban population.