Herpes simplex virus type 1 shows multiple interactions with sulfonated compounds at binding, penetration, and cell-to-cell passage.
Herpes simplex virus type 1 shows multiple interactions with sulfonated compounds at binding, penetration, and cell-to-cell passage.
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1 型单纯疱疹病毒在结合、渗透和细胞间传代时与磺化化合物表现出多种相互作用。
DOI：
10.1007/s11262-006-0016-5
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发表时间：
2007
期刊：
影响因子：
1.6
通讯作者：
Wagner,EdwardK
中科院分区：
文献类型：
--
作者：
Aguilar,JoséSantiago;Held,KatherineS;Wagner,EdwardK
单纯疱疹病毒1型（HSV-1）使用多组分机制进行结合、穿透和细胞间传递。这些过程受到多磺化化合物的影响。在本文中，我们已经解决的问题，是否相同或不同的相互作用的HSV-1与多磺化化合物参与结合，渗透和通道。为此，我们比较了一系列已知可阻断HSV-1感染的聚磺化和阳离子化合物的抑制剂量反应。在结合、渗透和细胞间传代水平进行这些比较。剂量-反应曲线的参数-IC 50和Hill系数（nH）-的变化与HSV-1在所有这些过程中与磺化细胞组分具有多重相互作用一致。有些相互作用似乎是共同的三个进程，而其他人是每一个特定的。
Herpes simplex virus type 1 (HSV-1) uses multicomponent mechanisms for binding, penetration, and cell-to-cell passage. These processes are affected by polysulfonated compounds. In this paper we have addressed the question of whether the same or different interactions of HSV-1 with polysulfonated compounds are involved in binding, penetration, and passage. For this, we have compared the inhibitory dose–response for a series of polysulfonated and cationic compounds known to block HSV-1 infections. These comparisons were done at the level of binding, penetration, and cell-to-cell passage. Variations in the parameters of the dose–response curves––IC50and Hill coefficients (nH)––are consistent with HSV-1 having multiple interactions with sulfonated cellular components in all these processes. Some of the interactions seem to be common to the three processes, while others are particular for each one.