Suppression of pituitary and testicular function in normal men by constant gonadotropin-releasing hormone agonist infusion.
Suppression of pituitary and testicular function in normal men by constant gonadotropin-releasing hormone agonist infusion.
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通过持续输注促性腺激素释放激素激动剂抑制正常男性的垂体和睾丸功能。
DOI：
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发表时间：
1984
影响因子：
5.8
通讯作者：
E. Nieschlag
中科院分区：
文献类型：
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作者：
T. Schürmeyer;U. Knuth;C. W. Freischem;J. Sandow;F. B. Akhtar;E. Nieschlag
在一项男性生育控制试验中，研究了持续输注GnRH激动剂（布舍瑞林）对垂体和睾丸功能的影响。用体外渗透微型泵对两组正常青年男性皮下注射该激动剂12周。7名男性接受118 +/- 24（SD）微克/天，每两周更换一次泵，4名男性接受230 +/- 27微克/天，每周更换一次泵。血清LH、FSH和睾酮在初始升高后下降。在高剂量组中下降速度更快，并且这些受试者在治疗4周后对急性GnRH刺激无LH反应，而在接受低剂量的组中反应急剧降低。当受试者抱怨性欲和/或效力下降或当血清睾酮在第五周平均低于10 nmol/L时，开始用十一酸睾酮（每日口服80-120 mg）替代雄激素。精子计数显著降低，低于正常下限20，000，000/ml。高剂量组在给药第12周达到最低点，低剂量组在给药后第4周达到最低点。尽管垂体脱敏和睾丸功能受损，无精子症没有发生。似乎需要更高剂量的激动剂来实现这一目标。
In a trial for male fertility control the effects of constant GnRH agonist (buserelin) infusion on pituitary and testicular function was investigated. The agonist was administered sc for 12 weeks to two groups of normal young men using extracorporeal osmotic minipumps. Seven men received 118 +/- 24 (SD) micrograms/day from pumps changed biweekly and four men received 230 +/- 27 micrograms/day from pumps changed weekly. After an initial rise serum LH, FSH, and testosterone decreased. The decrease occurred faster in the high dose group and these subjects had no LH response to acute GnRH stimulation after 4 weeks of treatment, whereas the response was drastically reduced in the group receiving the low dose. Androgen substitution with testosterone undecanoate (80-120 mg orally daily) was initiated when the subjects complained of decreased libido and/or potency or when serum testosterone fell below 10 nmol/liter on average in the fifth week. Sperm counts decreased significantly and below the lower normal limit of 20,000,000/ml. The nadir was reached in week 12 of treatment in the high dose group, and in week 4 post treatment in the low dose group. Despite desensitization of the pituitary and impaired testicular function azoospermia did not occur. A higher dose of agonist appears to be required to achieve this goal.