Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-0114
Nectriatide, a Potentiator of Amphotericin B Activity from Nectriaceae sp. BF-0114
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Nectriatide，一种来自 Nectriaceae sp. 的两性霉素 B 活性增强剂。
DOI：
10.1021/acs.jnatprod.8b01056
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发表时间：
2019
影响因子：
5.1
通讯作者：
and Hiroshi Tomoda
中科院分区：
文献类型：
--
作者：
Takashi Fukuda;Kenichiro Nagai;Akiho Yagi;Keisuke Kobayashi;Ryuji Uchida;Tadashi Yasuhara;and Hiroshi Tomoda
从银杏发酵液中分离得到一个新化合物，命名为核苷(1)，作为两性霉素B(AMB)抗白色念珠菌活性的增效剂。BF-0114。该结构是通过光谱分析(一维和二维核磁共振数据)、化学方法和全合成得到的。化合物1是由L-N-甲基酪氨酸、邻氨基苯甲酸、L-丙氨酸和L-缬氨酸组成的一种独特的环四肽。化合物1和几种合成的衍生物，包括线状多肽，增强了Amb对C。对白色念珠菌的MIC值最高可达16倍(AMB的MIC值从0.50μg/mL降至0.031μg/mL)。
A new compound, designated nectriatide (1), was isolated as a potentiator of amphotericin B (AmB) activity againstCandida albicansfrom the culture broth ofNectriaceaesp. BF-0114. This structure was elucidated based on spectroscopic analyses (1D and 2D NMR data), chemical methods, and total synthesis. Compound1was a unique cyclotetrapeptide consisting ofl-N-methyltyrosine, anthranilic acid,l-alanine, andl-valine. Compound1and several synthetic derivatives, including linear peptides, potentiated AmB activity againstC. albicansby up to 16-fold (the MIC value of AmB decreased from 0.5 μg/mL to 0.031 μg/mL in combination with test compound).