New insights into the role of angiogenin in actin polymerization.
New insights into the role of angiogenin in actin polymerization.
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DOI：
10.1016/b978-0-12-394306-4.00011-3
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发表时间：
2012
影响因子：
--
通讯作者：
Kostyukova AS
中科院分区：
文献类型：
--
作者：
Pyatibratov MG;Kostyukova AS
血管生成素是血管生成的有效刺激剂。它与内皮细胞相互作用并诱导广泛的细胞反应，从而启动血管形成过程。血管生成素的一个重要靶标是内皮细胞表面肌动蛋白，它们的相互作用可能是血管生成素诱导的新血管形成的关键步骤之一。最近，研究表明血管生成素可抑制G-肌动蛋白的聚合并改变F-肌动蛋白的物理性质。这些观察结果表明血管生成素可能引起细胞骨架的变化。本章回顾了有关血管生成素结构和功能的文献现状，并讨论了血管生成素和肌动蛋白之间的关系以及它们相互作用的可能功能作用。
Angiogenin is a potent stimulator of angiogenesis. It interacts with endothelial cells and induces a wide range of cellular responses initiating a process of blood vessel formation. One important target of angiogenin is endothelial cell-surface actin, and their interaction might be one of crucial steps in angiogenin-induced neovascularization. Recently, it was shown that angiogenin inhibits polymerization of G-actin and changes the physical properties of F-actin. These observations suggest that angiogenin may cause changes in the cell cytoskeleton. This chapter reviews the current state of the literature regarding angiogenin structure and function and discusses the relationship between the angiogenin and actin and possible functional roles of their interaction.