Imprinted-like biopolymeric micelles as efficient nanovehicles for curcumin delivery.
Imprinted-like biopolymeric micelles as efficient nanovehicles for curcumin delivery.
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DOI：
10.1016/j.colsurfb.2014.08.033
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发表时间：
2014-11
期刊：
影响因子：
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通讯作者：
Lili Zhang;Zeyou Qi;Qiyu Huang;Ke Zeng;Xiaoyi Sun;Juan Li;Younian Liu
中科院分区：
文献类型：
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作者：
Lili Zhang;Zeyou Qi;Qiyu Huang;Ke Zeng;Xiaoyi Sun;Juan Li;Younian Liu
为了提高疏水性姜黄素的溶解度和生物利用度，设计了一种新型的生物聚合物胶束（IBMs）。通过将明胶-葡聚糖缀合物与亲水性茶多酚共组装，然后将组装好的胶束交联，最后通过透析去除模板茶多酚。所获得的ibm对多酚类药物的选择性结合优于其他药物。此外，姜黄素可以有效地包封在IBMs中，其水溶性提高了5 × 104倍。我们观察了载姜黄素的IBMs （CUR@IBMs）在典型生物缓冲液中的持续药物释放行为。此外，我们发现CUR@IBMs的细胞摄取远高于游离姜黄素。细胞毒性实验结果表明，与游离姜黄素相比，CUR@IBMs可改善HeLa细胞的生长抑制，而空白IBMs的细胞毒性较小。体内动物实验表明，IBMs能显著提高姜黄素的口服生物利用度。
To enhance the solubility and improve the bioavailability of hydrophobic curcumin, a new kind of imprinted-like biopolymeric micelles (IBMs) was designed. The IBMs were prepared via co-assembly of gelatin–dextran conjugates with hydrophilic tea polyphenol, then crosslinking the assembled micelles and finally removing the template tea polyphenol by dialysis. The obtained IBMs show selective binding for polyphenol analogous drugs over other drugs. Furthermore, curcumin can be effectively encapsulated into the IBMs with 5 × 104-fold enhancement of aqueous solubility. We observed the sustained drug release behavior from the curcumin-loaded IBMs (CUR@IBMs) in typical biological buffers. In addition, we found the cell uptake of CUR@IBMs is much higher than that of free curcumin. The cell cytotoxicity results illustrated that CUR@IBMs can improve the growth inhibition of HeLa cells compared with free curcumin, while the blank IBMs have little cytotoxicity. The in vivo animal study demonstrated that the IBMs could significantly improve the oral bioavailability of curcumin.