The effect of vaccination on foot and mouth disease virus transmission among dairy cows
The effect of vaccination on foot and mouth disease virus transmission among dairy cows
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DOI：
10.1016/j.vaccine.2006.07.030
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发表时间：
2007-01-04
期刊：
影响因子：
5.5
通讯作者：
Dekker, A.
中科院分区：
文献类型：
--
作者：
Orsel, K.;de Jong, M. C. M.;Dekker, A.
本研究的目的是量化奶牛单次接种疫苗对口蹄疫病毒（FMDV）传播的影响。为了估计接种疫苗是否可以显著减少病毒传播，我们对一组接种疫苗和一组未接种疫苗的奶牛（每组10头动物）进行了两次重复的传播实验。两组中的一半动物鼻内接种FMDV田间分离株O/NET 2001，并从第二天开始与另一半动物（接触暴露奶牛）一起圈养。通过估计繁殖率R来量化病毒传播，繁殖率R是由一只感染性动物引起的继发病例的平均数量。在未接种组中，所有奶牛均被感染，R-CRP显著高于1。在接种组中，在3头接种奶牛中证实了感染，未观察到传播（R为0，不显著低于1）。与未接种母牛组相比，接种母牛组的传播显著降低。我们的研究结果表明，在单次接种疫苗后，奶牛可以免受FMD感染，并且在接种疫苗的牛群中很可能不会发生病毒传播。(c)2006爱思唯尔有限公司保留所有权利。
The aim of this study was to quantify the effect of a single vaccination of dairy cows on foot and mouth disease virus (FMDV) transmission. To estimate if vaccination could significantly reduce virus transmission, we performed two replicates of a transmission experiment with one group of vaccinated and one group of non-vaccinated dairy cows (ten animals per group). Half of both groups were intranasally inoculated, with FMDV field isolate O/NET2001, and housed with the other half of the group (contact-exposed cows) from the next day onwards. Virus transmission was quantified by estimating the reproduction ratio R, which is the average number of secondary cases caused by one infectious animal. In the non-vaccinated groups all cows became infected and R-nv, was significantly above 1. In the vaccinated groups infection was demonstrated in three inoculated cows, and no transmission was observed (R, was 0, not significantly below 1). Transmission was significantly reduced in the groups of vaccinated cows when compared to the groups of unvaccinated cows. Our findings indicate that after a single vaccination cows are protected against infection of FMD and that most likely no virus transmission will occur within a vaccinated herd. (c) 2006 Elsevier Ltd. All rights reserved.