Changes in serum inhibin, activin and follistatin concentrations during puberty in girls.
Changes in serum inhibin, activin and follistatin concentrations during puberty in girls.
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女孩青春期血清抑制素、激活素和卵泡抑素浓度的变化。
DOI：
10.1093/humrep/15.5.1052
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Padmanabhan,V
中科院分区：
文献类型：
--
作者：
Foster,CM;Phillips,DJ;Wyman,T;Evans,LW;Groome,NP;Padmanabhan,V
采用双位点酶联免疫吸附试验（ELISA）测定了28名女孩和5名卵泡期妇女青春期卵巢发育过程中血清中卵泡抑素（FSH）、卵泡素A、卵泡素B、激活素A的浓度。将每隔15至20分钟过夜获得的血液合并用于肽测定。青春期中期，血清雌二醇水平与骨龄（r= 0.581，P = 0.0005）呈正相关（r= 0.527，P = 0.0016）。抑制素B浓度在青春期中期达到峰值，此后下降，但仍高于青春期前女孩的浓度，并与雌二醇（r= 0.362，P = 0.046）和卵泡刺激素（FSH）浓度（r= 0.369，P = 0.038）呈正相关。总激活素A浓度在青春期各阶段无显著差异。放射免疫法测定的卵泡抑素总浓度随青春期的提前而降低，与骨龄（r=-0.634，P = 0.0001）和雌二醇浓度（r=-0.687，P = 0.0001）呈负相关。卵泡抑素288特异性ELISA测定的卵泡抑素浓度在青春期中期女孩中最高，但青春期后期的浓度低于青春期早期。游离卵泡抑素试验表明，所有循环卵泡抑素激活素结合。这些结果表明，FSH调节肽的血清浓度的显着变化伴随着青春期的开始。
Serum concentrations of inhibin A, inhibin B, activin A and follistatin were determined using two-site enzyme-linked immunosorbent assays (ELISA) during pubertal ovarian development in 28 girls and five follicular phase women. Blood obtained every 15 to 20 min overnight was pooled for peptide determination. Serum inhibin A concentrations increased in mid puberty, exhibiting positive correlations with bone age (r= 0.527,P= 0.0016) and oestradiol concentrations (r= 0.581,P= 0.0005). Inhibin B concentrations peaked in mid puberty and declined thereafter, but remained greater than concentrations seen in prepubertal girls, and correlating positively with oestradiol (r= 0.362,P= 0.046) and follicle stimulating hormone (FSH) concentrations (r= 0.369,P= 0.038). Total activin A concentrations did not vary significantly across pubertal stages. Total follistatin concentrations, determined by radioimmunoassay, decreased with advancing puberty, exhibiting negative correlations with bone age (r= –0.634,P= 0.0001) and oestradiol concentration (r= –0.687,P= 0.0001). Follistatin concentrations determined by an ELISA specific for follistatin 288 were greatest in mid-pubertal girls, but concentrations in late puberty were less than those in early puberty. The free follistatin assay indicated that all circulating follistatin was activin-bound. These results suggest that significant changes in serum concentrations of FSH-regulatory peptides accompany the onset of puberty.
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抑制素 B 的减少和激活素 A 的增加导致的刺激输入的净增加可能在一定程度上导致了老年骑行女性的卵泡期促卵泡激素的增加。
DOI：
10.1210/jcem.83.9.5130
发表时间：
1998
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
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DOI：
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发表时间：
1998
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
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DOI：
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发表时间：
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期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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影响因子：
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作者：
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DOI：
10.1210/jcem.79.1.7517947
发表时间：
1994
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
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作者：
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通讯作者：
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