THE GENETIC-BASIS OF DEVELOPMENTAL STABILITY .1. RELATIONSHIPS BETWEEN STABILITY, HETEROZYGOSITY AND GENOMIC COADAPTATION
THE GENETIC-BASIS OF DEVELOPMENTAL STABILITY .1. RELATIONSHIPS BETWEEN STABILITY, HETEROZYGOSITY AND GENOMIC COADAPTATION
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DOI：
10.1007/bf02424502
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发表时间：
1993-01-01
期刊：
影响因子：
1.5
通讯作者：
CLARKE, GM
中科院分区：
文献类型：
--
作者：
CLARKE, GM
在过去的40年里，发育稳定性的遗传基础一直备受争议。在这一时期，人们提出了两个主要的假说，一个认为稳定性水平反映了基因组杂合性的潜在水平，另一个认为稳定性反映了基因组共适应的总体水平，即基因平衡。在这篇论文中，我试图从实践和理论两个角度批判性地回顾这些假说的证据。总的来说，几乎没有令人信服的证据表明杂合性在决定和维持发育稳定性方面发挥着重要作用，而基因组共适应假说得到了相当大的支持。
The genetic basis of developmental stability has been much debated over the last four decades. Two major hypotheses have been developed over this period, one that argues that the level of stability is a reflection of the underlying level of genomic heterozygosity and the other that stability reflects the general level of genomic coadaptation, or genic balance. In this paper I have attempted to critically review the evidence for these hypotheses from both practical and theoretical perspectives. On balance there is little convincing evidence to suggest that heterozygosity plays a significant role in the determination and maintenance of developmental stability, whereas there is considerable support for the genomic coadaptation hypothesis.