Higher white blood cell counts are associated with an increased risk for metabolic syndrome and more severe psychopathology in non-diabetic patients with schizophrenia
Higher white blood cell counts are associated with an increased risk for metabolic syndrome and more severe psychopathology in non-diabetic patients with schizophrenia
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DOI：
10.1016/j.schres.2010.02.1028
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发表时间：
2010-05-01
影响因子：
4.5
通讯作者：
Henderson, David C.
中科院分区：
文献类型：
--
作者：
Fan, Xiaoduo;Liu, Emily Y.;Henderson, David C.
背景：已经出现明确的证据表明炎症与代谢问题的风险有关。先前的研究还表明炎症与精神分裂症之间存在关系。本研究探讨了白细胞计数（WBC）（全身炎症标志物）是否与非糖尿病精神分裂症患者的代谢综合征和精神症状相关。方法：19至75岁诊断为精神分裂症或分裂情感性障碍的门诊患者参与了一项多中心、横断面研究。获得生命体征和人体测量数据。收集空腹血样以确定葡萄糖、血脂和白细胞的水平。使用简明精神病评定量表 (BPRS) 评估精神症状。 结果：在 199 名患者的样本中，多重逻辑回归显示，在考虑了包括年龄、性别、种族、发病年龄、糖尿病家族史、吸烟状况和使用的抗精神病药物等潜在混杂变量后，WBC（对数转换）强烈预测代谢综合征的状况（比值比 47.2，95% Cl 3.4-658.7，p = 0.004）。另一方面，考虑到潜在的混杂变量后，WBC（对数转换）与 BPRS 总评分（r = 0.18，p = 0.014）、阴性症状评分（r = 0.15，p = 0.039）以及焦虑抑郁因素评分（r = 0.21，p = 0.004）之间存在显着相关性。这种廉价的措施可能是预测非糖尿病精神分裂症患者代谢综合征风险增加和更严重精神症状的有用标记。 (C) 2010 Elsevier B.V. 保留所有权利。
Background: Unequivocal evidence has emerged linking inflammation to the risk of metabolic problems. Previous research also has suggested a relationship between inflammation and schizophrenia. The present study examined whether white blood cell count (WBC), a marker of systemic inflammation, is associated with metabolic syndrome and psychiatric symptoms in non-diabetic patients with schizophrenia.Methods: Outpatients 19 to 75 years old diagnosed with schizophrenia or schizoaffective disorder participated in a multi-center, cross-sectional study. Vital signs and anthropometric measures were obtained. Fasting blood samples were collected to determine levels of glucose, lipids and WBC. Psychiatric symptoms were assessed using the Brief Psychiatric Rating Scale (BPRS).Results: In the sample of 199 patients, multiple logistic regression showed that WBC (log transformed) strongly predicted the condition of metabolic syndrome after potential confounding variables including age, gender, race, age of illness onset, family history of diabetes, smoking status and antipsychotic agent used were taken into consideration (odds ratio 47.2, 95% Cl 3.4-658.7, p = 0.004). On the other hand, significant correlations were found between WBC (log transformed) and BPRS-total score (r = 0.18, p = 0.014), negative symptom score (r = 0.15, p = 0.039) as well as anxious depression factor score (r = 0.21, p = 0.004) after potential confounding variables were taken into consideration.Conclusion: This study suggested that WBC, a simple, readily available and inexpensive measure, may potentially be a useful marker to predict an increased risk for metabolic syndrome and more severe psychiatric symptoms in non-diabetic patients with schizophrenia. (C) 2010 Elsevier B.V. All rights reserved.