Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics
Single-Cell Migration in Complex Microenvironments: Mechanics and Signaling Dynamics
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DOI：
10.1115/1.4032188
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发表时间：
2016-02-01
影响因子：
1.7
通讯作者：
Zaman, Muhammad H.
中科院分区：
文献类型：
--
作者：
Mak, Michael;Spill, Fabian;Zaman, Muhammad H.
细胞是高度动态的机械自动机，由分子马达驱动，对外部信号做出反应。细胞内信号传导途径，无论是化学的还是机械的，都可以被激活并在空间上协调以诱导极化细胞状态和定向迁移。在生理上，细胞在复杂的微环境中导航，通常在三维（3D）纤维网络中。在疾病中，如转移性癌症，它们侵入生理屏障，并通过力量，基质降解，合成和重组重塑其局部环境。重要的外部因素，如维度，限制，地形线索，刚度和流动影响迁移细胞的行为，并可以调节运动。在这里，我们回顾了我们对复杂微环境中单细胞迁移的理解的最新进展。
Cells are highly dynamic and mechanical automata powered by molecular motors that respond to external cues. Intracellular signaling pathways, either chemical or mechanical, can be activated and spatially coordinated to induce polarized cell states and directional migration. Physiologically, cells navigate through complex microenvironments, typically in three-dimensional (3D) fibrillar networks. In diseases, such as metastatic cancer, they invade across physiological barriers and remodel their local environments through force, matrix degradation, synthesis, and reorganization. Important external factors such as dimensionality, confinement, topographical cues, stiffness, and flow impact the behavior of migrating cells and can each regulate motility. Here, we review recent progress in our understanding of single-cell migration in complex microenvironments.