Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane
Sex hormone-binding globulin mediates steroid hormone signal transduction at the plasma membrane
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DOI：
10.1016/s0960-0760(99)00070-9
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发表时间：
1999-04-01
影响因子：
4.1
通讯作者：
Romas, NA
中科院分区：
文献类型：
--
作者：
Rosner, W;Hryb, DJ;Romas, NA
性激素结合球蛋白是一种血浆糖蛋白，能与某些雌激素和雄激素高亲和力结合。在过去的几年里，已经表明，除了作为一个调节器的自由浓度的类固醇激素的数量，SHBG在允许某些类固醇激素不进入细胞发挥作用的核心作用。这个系统很复杂。SHBG与细胞膜上的特异性高亲和力受体（R-SHBG）相互作用，该受体似乎通过G蛋白抑制其信号。SHBG-R-SHBG复合物在暴露于适当的类固醇后几分钟内引起腺苷酸环化酶的激活和cAMP的产生。只有与SHBG结合的类固醇才能激活SHBG-RSHBG，但并非所有结合的类固醇都具有这种功能，例如激动剂。所有与SHBG结合但不激活腺苷酸环化酶的类固醇都是拮抗剂。由类固醇-SHBG-R-SHBG复合物产生的信号产生对类固醇激素的经典细胞内受体的转录活性有影响的信息。这些和其他下游的影响，该系统进行审查。(C)1999 Elsevier Science Ltd.保留所有权利。
Sex hormone-binding globulin is a plasma glycoprotein that binds certain estrogens and androgens with high affinity. Over the past several years it has been shown that, in addition to functioning as a regulator of the free concentration of a number of steroid hormones, SHBG plays a central role in permitting certain steroid hormones to act without entering the cell. The system is complex. SHBG interacts with a specific, high affinity receptor (R-SHBG) on cell membranes that appears to transduce its signal via a G protein. The SHBG-R-SHBG complex causes the activation of adenylyl cyclase and the generation of cAMP within a matter of minutes after exposure to an appropriate steroid. Only steroids that bind to SHBG can activate SHBG-RSHBG, but not all steroids that bind have this function, e.g. are agonists. All steroids that bind to SHBG but do not activate adenylyl cyclase are antagonists. The signals generated by the steroid-SHBG-R-SHBG complex generate messages that have effects on the transcriptional activity of classic, intracellular receptors for steroid hormones. These and other downstream effects of this system are reviewed. (C) 1999 Elsevier Science Ltd. All rights reserved.